Registration Dossier
Registration Dossier
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EC number: 209-132-5 | CAS number: 556-61-6
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.053 µg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.531 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.005 µg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 0.18 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.431 µg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.043 µg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no exposure of soil expected
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Conclusion on classification
The acute toxicity of Methyl isothiocyanate was evaluated with Oncorhynchus mykiss in a study performed in accordance with OECD testing guideline 203 and GLP requirements. LC50-96 h was estimated using measured concentrations as being equal to 0.0531 mg/L.
The acute toxicity of Methyl isothiocyanate was evaluated with Daphnia magna in a study performed in accordance with OECD testing guideline 202 and GLP requirements.EC50-48 h was estimated using measured concentrations as being equal to 0.076 mg/L.
The acute toxicity of Methyl isothiocyanate was evaluated with Pseudokirschneriella subcapitat ain a study performed in accordance with OECD testing guideline 201 and GLP requirements.ECr50-72 h was estimated using measured concentrations as being equal to 0.58 mg/L. (For information, ECb50-72 h was estimated equal to 0.28 mg/L).
The ready biodegradability of methyl isothiocyanate was evaluated in a study performed in accordance with OECD testing guideline 301 D and GLP requirements. The maximum level of biodegradation was 0 % in 28 days. Therefore, according to these results, methyl isothiocyanate is not considered as readily biodegradable.
As a consequence, according to 67/548 CEE criteria Methyl isothiocyanate must be classified as 50/53 and Aquatic acute and chronic category I with M-factors =10 with regards to CLP criteria.
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