Registration Dossier
Registration Dossier
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EC number: 209-132-5 | CAS number: 556-61-6
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Fatal poisoning with wethyl isothiocyanate.
- Author:
- Sharma BK, Singh S, and Mehta R.
- Year:
- 1 981
- Bibliographic source:
- British Medical Journal, volume 283
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl isothiocyanate
- EC Number:
- 209-132-5
- EC Name:
- Methyl isothiocyanate
- Cas Number:
- 556-61-6
- Molecular formula:
- C2H3NS
- IUPAC Name:
- isothiocyanatomethane
- Details on test material:
- MITC was purchased from Mann Laboratories Inc, NY.
Constituent 1
Method
- Type of population:
- general
- Subjects:
- A 23-year-old chemistry student (woman).
- Route of exposure:
- oral
- Reason of exposure:
- intentional
- Exposure assessment:
- estimated
- Details on exposure:
- 50 mg MITC in drinking water
- Examinations:
- Patient was brought to the emergency department of Nehru Hospital within 20 minutes after intentionally drinking water containing MITC.
- Medical treatment:
- Gastric lavage was performed with sodium thiosufphate, and sodium nitrite and sodium thiosulphate were given intraveinously diapezam, and she was put on respirator. Peritonoeal dialysis was instituted about one hours after admission.
Results and discussion
- Clinical signs:
- Immediately after ingestion she had noticed severe retrosternal burning and epigastric pain and begun to vomit repeatedly. A few minutes later she began generalised tonic and clonic seizures and became unconcious. She was admitted deeply comatose and with pulse 98/min and blood presssure 90/60 mmHg. Chest, heart, and abdomen were normal. The pupils were slightly dilated but equal in size and reacted sluggishly to light. There was complete perte of all reflex and motor activity including oculocephalic reflex.
- Results of examinations:
- Necropsy a few hours later showed extensive mucosal necrosis of oesophagus, stomach, and proximal part of duodenum. Other organs showed only evidence of shock.
- Effectivity of medical treatment:
- no data
- Outcome of incidence:
- After medical treatement, she continued to deteriorate with a further fall in blood pressure, however, and died about eight hours after admission.
Applicant's summary and conclusion
- Conclusions:
- A woman student was died after drinking water with MITC.
- Executive summary:
A 23-year-old chemistry student (woman) swallow 50 mg MITC in drinking water to suicide her.
Immediately after ingestion she had noticed severe retrosternal burning and epigastric pain and begun to vomit repeatedly. A few minutes later she began generalised tonic and clonic seizures and became unconcious. She was admitted deeply comatose and with pulse 98/min and blood presssure 90/60 mmHg. Chest, heart, and abdomen were normal. The pupils were slightly dilated but equal in size and reacted sluggishly to light. There was complete perte of all reflex and motor activity including oculocephalic reflex.
Gastric lavage was performed with sodium thiosufphate, and sodium nitrite and sodium thiosulphate were given intraveinously diapezam, and she was put on respirator. Peritonoeal dialysis was instituted about one hours after admission. After medical treatement, she continued to deteriorate with a further fall in blood pressure, however, and died about eight hours after admission. Necropsy a few hours later showed extensive mucosal necrosis of oesophagus, stomach, and proximal part of duodenum. Other organs showed only evidence of shock.
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