Bis(4-chlorophenyl) sulphone

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

other information

Study period:

1981

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

An Acute Inhalation Hazard Test is assaying the toxicity of an atmosphere maximally saturated with a vapor of a test substance. Due to the very low vapor pressure of DCDPS this assay type is therefore not applicable for the determination of an acute lethal dose.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Principles of method if other than guideline:

The test was performed according to the method described by Smyth et al (1962). Rats were exposed to DCDPS vapour saturated air during 7 h.
- Smyth et al (1962). Am Ind Hyg Ass J 23:95-107.

GLP compliance:

no

Test type:

other: Inhalation hazard test (IHT)

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Bis(4-chlorophenyl) sulphone

EC Number:

201-247-9

EC Name:

Bis(4-chlorophenyl) sulphone

Cas Number:

80-07-9

Molecular formula:

C12H8Cl2O2S

IUPAC Name:

1-chloro-4-(4-chlorobenzenesulfonyl)benzene

Details on test material:

- Name of test material (as cited in study report): 4,4'-dichlorodiphenyl sulfone
- Physical state: solid
- Analytical purity: not reported

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

TEST ATMOSPHERE
- Samples taken from breathing zone: no

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

7 h

Concentrations:

The nominal concentration calculated as quotient of the amount of the test substance weight loss during exposure was 0 mg/kg bw.
The vapour saturation concentration of the test substance calculated based on the ideal gas law (n/v=P/(R•T)) using the vapour pressure (0.000015 Pa, Habeck 2010) at 25 °C delivers a molar concentration of 6E-9 mol/m³ and after multiplication with the molecular weight (287.1617 g/mol) it is calculated to 1.74 ng/L.

No. of animals per sex per dose:

12

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

ca. 0.002 mg/m³ air

Based on:

test mat.

Exp. duration:

7 h

Remarks on result:

other: no mortalities observed

Mortality:

no mortalities were observed.

Clinical signs:

other: no clinical signs were observed.

Gross pathology:

no alterations were observed.

Applicant's summary and conclusion

Conclusions:

No relevand exposure was achieved under the experimental conditions, thus the study is not conclusive and not relevant