Registration Dossier
Registration Dossier
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EC number: 279-420-3 | CAS number: 80206-82-2
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: screening tests
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: QSAR method cited as reliable in the REACH guidance
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- QSAR-BioWin v 4.10
- GLP compliance:
- no
- Remarks:
- not applicable. QSAR model
- Oxygen conditions:
- other: QSAR
- Inoculum or test system:
- other: QSAR
- Details on inoculum:
- QSAR
- Parameter:
- other: BIOWIN v4.10
- Remarks on result:
- other: Ready Biodegradability Prediction: YES
- Details on results:
- --------------------------- BIOWIN v4.10 Results ----------------------------
Biowin1 (Linear Model Prediction) : Biodegrades Fast
Biowin2 (Non-Linear Model Prediction): Biodegrades Fast
Biowin3 (Ultimate Biodegradation Timeframe): Weeks
Biowin4 (Primary Biodegradation Timeframe): Days
Biowin5 (MITI Linear Model Prediction) : Biodegrades Fast
Biowin6 (MITI Non-Linear Model Prediction): Biodegrades Fast
Biowin7 (Anaerobic Model Prediction): Biodegrades Fast
Ready Biodegradability Prediction: YES - Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The BIOWIN QSAR predicts that the substance Alcohols, C12-14 will be readily biodegradable.
- Executive summary:
The estimated Biodegradetion in Water was measured by calculation from EPI SuiteTM v4.1/BIOWIN v4.10 Program and Ready Biodegradation was predicted. This is Exposure Assessment Tools and Models made from EPA (Environmental Protection Agency).
BIOWIN v4.10 Results
Biowin1 (Linear Model Prediction) : Biodegrades Fast
Biowin2 (Non-Linear Model Prediction): Biodegrades Fast
Biowin3 (Ultimate Biodegradation Timeframe): Weeks
Biowin4 (Primary Biodegradation Timeframe): Days
Biowin5 (MITI Linear Model Prediction) : Biodegrades Fast
Biowin6 (MITI Non-Linear Model Prediction): Biodegrades Fast
Biowin7 (Anaerobic Model Prediction): Biodegrades Fast
Ready Biodegradability Prediction: YES
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Qualifier:
- according to guideline
- Guideline:
- other: BOD-test for Insoluble Substances (BODIS); ISO 10708 (1997)
- Principles of method if other than guideline:
- Method:BOD-test for Insoluble Substances (BODIS); ISO 10708 (1997)
Water quality-Evaluation in an aqueous medium of the ultimate aerobic biodegradability of organic compounds - Determination of biochemical oxygen demand in a two-phase closed bottle test.
The test method used is based on OECD test method 301D and the RDA-Blok-Test. Mineral medium was inoculated with activated sludge and stabilized for one week at 18-22 C with continuous stirring. After stabilisation, 200 ml of test medium was filled into 300 ml bottles, aerated until O2 saturation was reached and spiked with test substance by directly weighing into the test vessels.
Vessels were filled 2/3, stoppered and shaken continuously at 18-22 C. Degradation was followed by weekly measurements of BOD using an O2-electrode. Oxygen consumption resulting from biodegradation of the test substance was corrected by oxygen uptake of blank inoculum. Degradation rate was calculated as % BOD/ThOD. - GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: effluent from domestic sewage treatment plant (appr.1000 - 100000 cells/ml)
- Details on inoculum:
- effluent from domestic sewage treatment plant (appr.1000 - 100000 cells/ml)
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- ThOD/L
- Reference substance:
- other: Sodium acetate
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 11 - 17
- Sampling time:
- 2 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 14 - 74
- Sampling time:
- 11 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 69 - 85
- Sampling time:
- 14 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 75 - 91
- Sampling time:
- 21 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 79 - 97
- Sampling time:
- 28 d
- Details on results:
- Degradation: = 79 - 97 % after 28 day(s) , the substance is considered to be readily biodegradable.
- Results with reference substance:
- Kinetic of control substance:
2 days = 28 - 33%
7 days = 76 - 73%
14 days = 82 - 80%
21 days = 84 -84%
28 days = 87 - 86% - Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Degradation: = 79 - 97 % after 28 day(s) , the substance is considered to be readily biodegradable.
- Executive summary:
Degradation: = 79 - 97 % after 28 day(s) , the substance is considered to be readily biodegradable.
.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- other: published data
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- ISO Draft (BOD Test for Insoluble Substances)
- Principles of method if other than guideline:
- Method: two phase closed bottle test
- GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, adapted
- Details on inoculum:
- effluent from predominantly domestic sewage treatment plant
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 50 mg/L
- Based on:
- COD
- Reference substance:
- not specified
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 56 - 62
- Sampling time:
- 28 d
- Details on results:
- Degradation: = 56 - 62 % after 28 day(s) , the substance is considered to be readily biodegradable.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Degradation: = 56 - 62 % after 28 day(s) , the substance is considered to be readily biodegradable.
- Executive summary:
Degradation: = 56 - 62 % after 28 day(s) , the substance is considered to be readily biodegradable.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- other: published data
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Principles of method if other than guideline:
- Method: EEC-Directive 92/69/EEC Annex V, Part C: Methods for the Determination of ecotoxicity.
C.4. Biodegradation: determination of the 'ready biodegradability' C.4-E.
This method corresponds to OECD test method 301D. - GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: effluent of predominantly domestic sewage treatment plant
- Details on inoculum:
- INOCULUM/TEST ORGANISM
Sampling site: Plant Hochdahl, Germany
INITIAL TEST SUBSTANCE CONCENTRATION: 2 and 5 mg/l
METHOD OF PREPARATION OF TEST SOLUTION: an inert emulsifier (nonylphenol ethoxylated propoxylated, NP+9.5 EO+5PO) was used to disperse the test substance. Concentration of emulsifier not reported. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 2 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Composition of medium: not reported
- Additional substrate: none
- Solubilising agent (type and concentration if used): an inert emulsifier (nonylphenol ethoxylated propoxylated, NP+9.5 EO+5PO) was used to disperse the test substance. Concentration of emulsifier not reported.
- Test temperature: 20 +/- 1C
- pH: not reported
- Aeration of dilution water: not reported
- Suspended solids concentration: not reported
- Nitrate/nitrite measurement: Yes
TEST SYSTEM
- Initial test substance concentration: 2 and 5 mg/l
CONTROL AND BLANK SYSTEM
Controls: mineral medium/ mineral medium with inoculum/mineral medium with inoculum and emulsifier. Degradation rate of test substance was corrected by oxygen uptake of blank inoculum and emulsifier control. - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (DOC removal)
- Value:
- 54
- Sampling time:
- 7 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 68
- Sampling time:
- 14 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 80
- Sampling time:
- 21 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 79
- Sampling time:
- 28 d
- Details on results:
- Degradation: = 79 % after 28 day(s) , the substance is considered to be readily biodegradable.
The test substance (2 mg/l) attained >60% degradation during the 14 day window.
The values reported in the results section are for the 2 mg/l concentration. The 5 mg/l concentration of test substance had insufficient residual dissolved oxygen content after 21 days. - Results with reference substance:
- The reference substance attained a biodegradation value of 88% in 28 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Degradation: = 79 % after 28 day(s) , the substance is considered to be readily biodegradable.Dodecan-1-ol (C12) is supporting substance for Alcohols,C12-C14 and the main component.
The test substance (2 mg/l) attained >60% degradation during the 14 day window.
The values reported in the results section are for the 2 mg/l concentration. The 5 mg/l concentration of test substance had insufficient residual dissolved oxygen content after 21 days. - Executive summary:
Degradation: = 79 % after 28 day(s) , the substance is considered to be readily biodegradable.
The test substance (2 mg/l) attained >60% degradation during the 14 day window.
The values reported in the results section are for the 2 mg/l concentration. The 5 mg/l concentration of test substance had insufficient residual dissolved oxygen content after 21 days.
.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- other: published data
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 10708 (BODIS)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Principles of method if other than guideline:
- Method: The test method used is based on OECD test method 301D and the RDA-Blok-Test. It is especially suitable for poorly water-soluble compounds. The test medium is inoculated and the test chemical added. The test vessels are then closed and shaken continuously.
Weekly measurements of the BOD from the aqueous phase are taken. - GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- Concentration of activated sludge: 30 mg dry matter/l
Test volume: 200 ml
Temperature: 20-25 C
pH: not reported - Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- COD
- Details on study design:
- Total oxygen uptake in flasks is calculated from blank-corrected decrease in measured dissolved oxygen concentration divided by saturation value at normal conditions and multiplied with total oxygen content originally present in liquid and gas phase.
- Reference substance:
- other: sodium acetate trihydrate
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 72
- Sampling time:
- 7 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 89
- Sampling time:
- 14 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 93
- Sampling time:
- 21 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 100
- Sampling time:
- 28 d
- Details on results:
- Degradation: = 100 % after 28 day(s) , the substance is considered to be readily biodegradable.
The substance degraded >60% in the 10 day window. - Results with reference substance:
- The reference substance attained a biodegradation value of 88% in 28 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Degradation: = 100 % after 28 day(s) , the substance is considered to be readily biodegradable.
The substance degraded >60% in the 10 day window. .Dodecan-1-ol (C12) is supporting substance for Alcohols,C12-C14 and the main component. - Executive summary:
Degradation: = 100 % after 28 day(s) , the substance is considered to be readily biodegradable.
The substance degraded >60% in the 10 day window. .Dodecan-1-ol (C12) is supporting substance for Alcohols,C12-C14 and the main component.
.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- other: published data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Principles of method if other than guideline:
- This test method corresponds to OECD 301B
The following validity criteria were met:
(1) the blanks were valid for this test, the maximum milligrams of carbon dioxide were well within the 40 mg/l range,
(2) both sodium acetate samples obeyed the 10-60% rule, no days were required for the bacterial population to acclimate to the sodium acetate,
(3) Parallel assays did not differ by more than 20%. - GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 20 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium:
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: Flasks
- Number of culture flasks/concentration: 6 flasks per sample, 3L of solution per flask
- Method used to create aerobic conditions: Continuous aeration or mixing
SAMPLING
- Sampling frequency: Continuous - Reference substance:
- other: Sodium acetate
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 16
- Sampling time:
- 4 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 44
- Sampling time:
- 8 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 60
- Sampling time:
- 14 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 71
- Sampling time:
- 28 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 73
- Sampling time:
- 46 d
- Details on results:
- Degradation: = 71 % after 28 day(s) , the substance is considered to be readily biodegradable.
The substance degraded >60% in the 14 day window. .Dodecan-1-ol (C12) is supporting substance for Alcohols,C12-C14 and the main component. The reference substance Sodium acetate degraded by 78% after 28 days. - Results with reference substance:
- Reference substance = 78% in 28 days
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Degradation: = 71 % after 28 day(s) , the substance is considered to be readily biodegradable.
The substance degraded >60% in the 14 day window. .Dodecan-1-ol (C12) is supporting substance for Alcohols,C12-C14 and the main component. The reference substance Sodium acetate degraded by 78% after 28 days. - Executive summary:
Degradation: = 71 % after 28 day(s) , the substance is considered to be readily biodegradable.
The substance degraded >60% in the 14 day window. .Dodecan-1-ol (C12) is supporting substance for Alcohols,C12-C14 and the main component. The reference substance Sodium acetate degraded by 78% after 28 days.
Referenceopen allclose all
IOWIN (v4.10) Program Results:
==============================
SMILES : CCCCCCCCCCCCO
CHEM : Alcohols, C12-14
MOL FOR: C13H28O
MOL WT : 200.37
--------------------------- BIOWIN v4.10 Results ----------------------------
Biowin1 (Linear Model Prediction) : Biodegrades Fast
Biowin2 (Non-Linear Model Prediction): Biodegrades Fast
Biowin3 (Ultimate Biodegradation Timeframe): Weeks
Biowin4 (Primary Biodegradation Timeframe): Days
Biowin5 (MITI Linear Model Prediction) : Biodegrades Fast
Biowin6 (MITI Non-Linear Model Prediction): Biodegrades Fast
Biowin7 (Anaerobic Model Prediction): Biodegrades Fast
Ready Biodegradability Prediction: YES
------+-----+--------------------------------------------+---------+---------
TYPE | NUM | Biowin1 FRAGMENT DESCRIPTION | COEFF | VALUE
------+-----+--------------------------------------------+---------+---------
Frag | 1 | Linear C4 terminal chain [CCC-CH3] | 0.1084 | 0.1084
Frag | 1 | Aliphatic alcohol [-OH] | 0.1587 | 0.1587
MolWt| * | Molecular Weight Parameter | | -0.0887
Const| * | Equation Constant | | 0.7475
============+============================================+=========+=========
RESULT | Biowin1 (Linear Biodeg Probability) | | 0.9260
============+============================================+=========+=========
------+-----+--------------------------------------------+---------+---------
TYPE | NUM | Biowin2 FRAGMENT DESCRIPTION | COEFF | VALUE
------+-----+--------------------------------------------+---------+---------
Frag | 1 | Linear C4 terminal chain [CCC-CH3] | 1.8437 | 1.8437
Frag | 1 | Aliphatic alcohol [-OH] | 1.1178 | 1.1178
MolWt| * | Molecular Weight Parameter | | -2.6460
============+============================================+=========+=========
RESULT | Biowin2 (Non-Linear Biodeg Probability) | | 0.9652
============+============================================+=========+=========
A Probability Greater Than or Equal to 0.5 indicates --> Biodegrades Fast
A Probability Less Than 0.5 indicates --> Does NOT Biodegrade Fast
------+-----+--------------------------------------------+---------+---------
TYPE | NUM | Biowin3 FRAGMENT DESCRIPTION | COEFF | VALUE
------+-----+--------------------------------------------+---------+---------
Frag | 1 | Linear C4 terminal chain [CCC-CH3] | 0.2983 | 0.2983
Frag | 1 | Aliphatic alcohol [-OH] | 0.1600 | 0.1600
MolWt| * | Molecular Weight Parameter | | -0.4118
Const| * | Equation Constant | | 3.1992
============+============================================+=========+=========
RESULT | Biowin3 (Survey Model - Ultimate Biodeg) | | 3.2457
============+============================================+=========+=========
------+-----+--------------------------------------------+---------+---------
TYPE | NUM | Biowin4 FRAGMENT DESCRIPTION | COEFF | VALUE
------+-----+--------------------------------------------+---------+---------
Frag | 1 | Linear C4 terminal chain [CCC-CH3] | 0.2691 | 0.2691
Frag | 1 | Aliphatic alcohol [-OH] | 0.1294 | 0.1294
MolWt| * | Molecular Weight Parameter | | -0.2688
Const| * | Equation Constant | | 3.8477
============+============================================+=========+=========
RESULT | Biowin4 (Survey Model - Primary Biodeg) | | 3.9774
============+============================================+=========+=========
Result Classification: 5.00 -> hours 4.00 -> days 3.00 -> weeks
(Primary & Ultimate) 2.00 -> months 1.00 -> longer
------+-----+--------------------------------------------+---------+---------
TYPE | NUM | Biowin5 FRAGMENT DESCRIPTION | COEFF | VALUE
------+-----+--------------------------------------------+---------+---------
Frag | 1 | Aliphatic alcohol [-OH] | 0.1611 | 0.1611
Frag | 1 | Methyl [-CH3] | 0.0004 | 0.0004
Frag | 11 | -CH2- [linear] | 0.0494 | 0.5436
MolWt| * | Molecular Weight Parameter | | -0.5544
Const| * | Equation Constant | | 0.7121
============+============================================+=========+=========
RESULT | Biowin5 (MITI Linear Biodeg Probability) | | 0.8629
============+============================================+=========+=========
------+-----+--------------------------------------------+---------+---------
TYPE | NUM | Biowin6 FRAGMENT DESCRIPTION | COEFF | VALUE
------+-----+--------------------------------------------+---------+---------
Frag | 1 | Aliphatic alcohol [-OH] | 1.0041 | 1.0041
Frag | 1 | Methyl [-CH3] | 0.0194 | 0.0194
Frag | 11 | -CH2- [linear] | 0.4295 | 4.7244
MolWt| * | Molecular Weight Parameter | | -5.3794
============+============================================+=========+=========
RESULT |Biowin6 (MITI Non-Linear Biodeg Probability)| | 0.9476
============+============================================+=========+=========
A Probability Greater Than or Equal to 0.5 indicates --> Readily Degradable
A Probability Less Than 0.5 indicates --> NOT Readily Degradable
------+-----+--------------------------------------------+---------+---------
TYPE | NUM | Biowin7 FRAGMENT DESCRIPTION | COEFF | VALUE
------+-----+--------------------------------------------+---------+---------
Frag | 1 | Linear C4 terminal chain [CCC-CH3] | -0.3177 | -0.3177
Frag | 1 | Aliphatic alcohol [-OH] | 0.1328 | 0.1328
Frag | 1 | Methyl [-CH3] | -0.0796 | -0.0796
Frag | 11 | -CH2- [linear] | 0.0260 | 0.2859
Const| * | Equation Constant | | 0.8361
============+============================================+=========+=========
RESULT | Biowin7 (Anaerobic Linear Biodeg Prob) | | 0.8574
============+============================================+=========+=========
A Probability Greater Than or Equal to 0.5 indicates --> Biodegrades Fast
A Probability Less Than 0.5 indicates --> Does NOT Biodegrade Fast
Ready Biodegradability Prediction: (YES or NO)
----------------------------------------------
Criteria for the YES or NO prediction: If the Biowin3 (ultimate survey
model) result is "weeks" or faster (i.e. "days", "days to weeks", or
"weeks" AND the Biowin5 (MITI linear model) probability is >= 0.5, then
the prediction is YES (readily biodegradable). If this condition is not
satisfied, the prediction is NO (not readily biodegradable). This method
is based on application of Bayesian analysis to ready biodegradation data
(see Help). Biowin5 and 6 also predict ready biodegradability, but for
degradation in the OECD301C test only; using data from the Chemicals
Evaluation and Research Institute Japan (CERIJ) database.
Two concentrations of effluent were tested:
5 ml/l and 50 ml/l. In the results section, the first value cited is for the 5 ml/l concentration and the second set refers to the 50ml/l concentration.The test substance degraded >60% over the test period, meeting the 10 day window criterion, therefore it is considered readily biodegradable..
Table: Degradation kinetics
Type of suspension |
% degradation at sampling time (days) |
|||
7 |
14 |
21 |
28 |
|
|
|
|
|
|
Test sample (2mg/l) |
54 |
68 |
80 |
79 |
|
|
|
|
|
Reference substance |
76 |
78 |
76 |
88 |
Description of key information
Biodegradation in water:screening tests
Data of following studies are demonstrating rapid biodegradation Alcohols, C12-14 under aerobic conditions.
Henkel KGaA. , 1997 conducted BOD-test for Insoluble Substances (BODIS); ISO 10708 for Biodegradation of Alcohols, C12-14.
The test method used is based on OECD test method 301D and the RDA-Blok-Test. Mineral medium was inoculated with activated sludge and stabilized for one week at 18-22 C with continuous stirring. After stabilisation, 200 ml of test medium was filled into 300 ml bottles, aerated until O2 saturation was reached and spiked with test substance by directly weighing into the test vessels.
Degradation was 79 - 97 % after 28 day(s), the substance is considered to be readily biodegradable
The BIOWIN QSAR predicts that the substance Alcohols, C12-14 will be readily biodegradable.
Richterich , 1993 conducted OECD 301D test for Biodegradation of Alcohols, C12 (1-Dodecanol). Degradation was 79 % after 28 day(s) , the substance is considered to be readily biodegradable. Dodecan-1-ol (C12) is supporting substance for Alcohols, C12-C14 and the main component. The test substance (2 mg/l) attained >60% degradation during the 14 day window.
Henkel KGaA. , 1992 conducted OECD test method 301D and BOD-test for Insoluble Substances (BODIS); ISO 10708 for Biodegradation of Dodecan-1-ol (C12. Degradation was 100 % after 28 day(s) , the substance is considered to be readily biodegradable.
The substance degraded >60% in the 10 day window. .Dodecan-1-ol (C12) is supporting substance for Alcohols, C12-C14 and the main component.
Morris, P.A., Filler, P.A., and Nielsen, A.M. (1991) conducted OECD 301B test and Degradationwas 71 % after 28 day(s) , the substance is considered to be readily biodegradable. The substance degraded >60% in the 14 day window. .Dodecan-1-ol (C12) is supporting substance for Alcohols,C12-C14 and the main component.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Biodegradation in water:screening tests
Data of following studies are demonstrating rapid biodegradation Alcohols, C12-14 under aerobic conditions.
Henkel KGaA. , 1997 conducted BOD-test for Insoluble Substances (BODIS); ISO 10708 for Biodegradation of Alcohols, C12-14.
The test method used is based on OECD test method 301D and the RDA-Blok-Test. Mineral medium was inoculated with activated sludge and stabilized for one week at 18-22 C with continuous stirring. After stabilisation, 200 ml of test medium was filled into 300 ml bottles, aerated until O2 saturation was reached and spiked with test substance by directly weighing into the test vessels.
Degradation was 79 - 97 % after 28 day(s), the substance is considered to be readily biodegradable
The BIOWIN QSAR predicts that the substance Alcohols, C12-14 will be readily biodegradable.
Richterich , 1993 conducted OECD 301D test for Biodegradation of Alcohols, C12 (1-Dodecanol). Degradation was 79 % after 28 day(s) , the substance is considered to be readily biodegradable. Dodecan-1-ol (C12) is supporting substance for Alcohols, C12-C14 and the main component. The test substance (2 mg/l) attained >60% degradation during the 14 day window.
Henkel KGaA. , 1992 conducted OECD test method 301D and BOD-test for Insoluble Substances (BODIS); ISO 10708 for Biodegradation of Dodecan-1-ol (C12. Degradation was 100 % after 28 day(s) , the substance is considered to be readily biodegradable.
The substance degraded >60% in the 10 day window. .Dodecan-1-ol (C12) is supporting substance for Alcohols, C12-C14 and the main component.
Morris, P.A., Filler, P.A., and Nielsen, A.M. (1991) conducted OECD 301B test and Degradationwas 71 % after 28 day(s) , the substance is considered to be readily biodegradable. The substance degraded >60% in the 14 day window. .Dodecan-1-ol (C12) is supporting substance for Alcohols,C12-C14 and the main component. The reference substance Sodium acetate degraded by 78% after 28 days.
Table Summary of Biodegradation in water:screening tests
Type/ Method |
Test material |
Degradation |
Duration |
References |
|
Aerobic/ OECD 301D/(BODIS) |
Alcohols, C12-14 |
79-97% in 28 days at 100 mg/L |
28 days |
Henkel KGaA. , 1997 |
|
Aerobic/ OECD 301D |
Alcohols, C12 (1-Dodecanol).
|
79%
|
28 days
|
Richterich , 1993 |
|
Aerobic/ OECD 301D/(BODIS |
Alcohols, C12 (1-Dodecanol).
|
100 % |
28 days |
Henkel KGaA. , 1992 |
|
Aerobic/ OECD 301D |
Alcohols, C12 (1-Dodecanol).
|
71 % |
28 days |
Morris, P.A., Filler, P.A., and Nielsen, A.M. (1991) |
|
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