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EC number: 279-420-3 | CAS number: 80206-82-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- The acute inhalation toxicity of Long Chain Alcohols (C6-22)
- Author:
- Veenstra, G.; Webb, C
- Year:
- 2 005
- Bibliographic source:
- Health effects SIAR for Long Chain Alcohols (C6-22) including Iuclid dossiers chapter 5 prepared for the Aliphatic Alcohols category
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: in house protocol
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Alcohols, C12-14
- EC Number:
- 279-420-3
- EC Name:
- Alcohols, C12-14
- Cas Number:
- 80206-82-2
- Molecular formula:
- C13H28O
- IUPAC Name:
- Alcohols, C12-14
- Details on test material:
- - Name of test material (as cited in study report): Alcohols, C12-14 Type A. 100% Linear; >90% C12/14 (C12>14), <10% C16 [range C6-C18]; Type B. 100% Linear; >95% C12/14 (C12<14) [range C8-C18]; Even
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS: Rat (Wistar)
- Source: Shell Toxicology Laboratory (Tunstall) Breeding Unit, Sittingbourne, Kent, UK
- Age: 8 weeks approx.
- Weight at study initiation: not reported
- Number of animals: 5M+5F
- Controls: none
Administration / exposure
- Route of administration:
- other: mist
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: Condensation mist atmosphere
- Details on inhalation exposure:
- ADMINISTRATION:
- Type of exposure: 4 hour inhalation exposure, whole body
- Concentrations: saturated atmosphere (no monitoring reported)
- Particle size: not reported
- Type or preparation of particles: condensation mist
EXAMINATIONS: Clinical signs observed throughout exposure and daily thereafter throughout an observation period of at least 14 days. Initial, 7 and 14 day bodyweights were recorded. - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- saturated atmosphere
- No. of animals per sex per dose:
- 5 male, 5 female
- Control animals:
- no
- Details on study design:
- Clinical signs observed throughout exposure and daily thereafter throughout an observation period of at least 14 days. Initial, 7 and 14 day bodyweights were recorded
- Statistics:
- No statistical analysis was carried out on the test results.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 4.9 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Type A,. LC50 expected to be > 4.9 ppm (substantially saturated atmospheric concentration)
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 40.08 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: To convert ppm into mg/m3 at 25°C and 760 mm Hg (101.32 kPa) mg/m3 =ppm x molecular weight /24.45. mg/m3 =4.9x 200/24.45=40.08 mg/m3
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1.3 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Type B. LC50 expected to be > 1.3 ppm (substantially saturated atmospheric concentration)
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 10.6 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: To convert ppm into mg/m3 at 25°C and 760 mm Hg (101.32 kPa) mg/m3 =ppm x molecular weight /24.45. mg/m3 =1.3 x 200/24.45=10.6 mg/m3
- Mortality:
- All animals survived the 4 hour exposure and subsequent observation period.
- Clinical signs:
- other: There were no signs of toxicity during or after exposure.
- Gross pathology:
- NECROPSY FINDINGS: Not carried out.
- Other findings:
- POTENTIAL TARGET ORGANS: None identified.
SEX-SPECIFIC DIFFERENCES: None reported.
Any other information on results incl. tables
To convert mg/m3 into ppm at 25°C and 760 mm Hg (101.32 kPa)
ppm = mg/m3 x 24.45
molecular weight
To convert ppm into mg/m3 at 25°C and 760 mm Hg (101.32 kPa)
mg/m3 =ppm x molecular weight
24.45
mg/m3 =4.9x 200 =40.08
24.45
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The 4 hour rat inhalational LC50 forAlcohols, C12-14 is >saturated vapour concentration. There were no signs of toxicity during exposure or the subsequent observation period..The rat 4 hour LC50 for Alcohols, C12-14 is > saturated vapour concentration.
- Executive summary:
The rat 4 hour LC50 for Alcohols, C12-14 is > saturated vapour concentration.
Alcohols,C12-14 are expected to be of a low order of acute inhalational toxicity with the LC50 in excess of the saturated vapour concentration
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