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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
other: published data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Interlaboratory evaluation of a human patch test for the identification of skin irritation potential/hazard.
Author:
Griffiths H A, Wilhelm K P, Robinson M K, Wang X M, McFadden J, York M, Basketter D A
Year:
1997
Bibliographic source:
Food and Chemical Toxicology 35: 255-260

Materials and methods

Type of study / information:
Type: other: human skin irritation
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
inter-laboratory assessment of the human patch testb using a Hill Top chamber
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Hexan-1-ol
EC Number:
203-852-3
EC Name:
Hexan-1-ol
Cas Number:
111-27-3
IUPAC Name:
hexan-1-ol
Details on test material:
- Analytical purity: not givenEC Name hexan-1-olCAS Name 1-HexanolCAS Number 111-27-3EC Number 203-852-3Molecular Formula C6H14O

Results and discussion

Any other information on results incl. tables

In this inter-laboratory assessment of the human patch test hexanol gave responses significantly lower than the positive control and results were 

similar between laboratories. N-hexanol was therefore not considered as a skin irritant.

Applicant's summary and conclusion

Conclusions:
In this inter-laboratory assessment of the human patch test hexanol gave responses significantly lower than the positive control and results were
similar between laboratories. N-hexanol was therefore not considered as a skin irritant.