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Ecotoxicological information

Toxicity to soil macroorganisms except arthropods

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Endpoint:
toxicity to soil macroorganisms except arthropods: long-term
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
Qualifier:
according to guideline
Guideline:
other: QSAR
Principles of method if other than guideline:
ECOSAR Program (v1.00)
GLP compliance:
no
Remarks:
not applicable to QSAR models
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
other: earthworm
Animal group:
other: QSAR model
Study type:
other: QSAR
Substrate type:
other: QSAR
Limit test:
no
Total exposure duration:
14 d
Test temperature:
not applicable. QSAR model
pH:
not applicable. QSAR model
Moisture:
not applicable. QSAR model
Details on test conditions:
CAS Number:80206-82-2
SMILES : CCCCCCCCCCCCO
CHEM : Alcohols, C12-14
MOL FOR: C12 H26 O1
MOL WT : 186.34
Log Kow: 4.77 (KowWin estimate)
Wat Sol: 4 mg/L (experimental database)
Reference substance (positive control):
no
Duration:
14 d
Dose descriptor:
LC50
Effect conc.:
167.217 mg/kg soil ww
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: (Q)SAR prediction
Remarks on result:
other: non-toxic at the limit of solubility, as determined by (Q)SAR
Details on results:
LC50 (14-day, earthworm)= 167.217 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 167.217 mg/kg soil dw
The ECOSAR QSAR model predicts that 14 -day LC50 value would to be 136.108 mg/L (ppm) for soil macroorganisms. Predicted to be non-toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.
The water solubility of the Alcohols, C12-14 is 4.0 mg/l at 25 degC (experimental database).
Reported statistics and error estimates:
US EPA accepted QSAR method for chemicals properties assessment.

Overview of QSARs estimations on toxicity of 

Alcohols, C12-14

to soil macroorganisms

Method

 

Results

Remarks

Reference

QSAR

estimate

LC50 (14-day, earthworm)= 167.217 mg/L (ppm)

 

 

Reliable withrestrictions,

QSAR estimated data

ECOSAR Program (v1.00)

 

 

LC50 (14-day, earthworm)= 167.217 mg/kg soil dw

Validity criteria fulfilled:
yes
Remarks:
US EPA accepted QSAR method for chemicals properties assessment.
Conclusions:
LC50 (14-day, earthworm)= 167.217 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 167.217 mg/kg soil dw
The ECOSAR QSAR model predicts that 14 -day LC50 value would to be 167.217mg/L (ppm) for soil macroorganisms. Predicted to be non-toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.
The water solubility of the Alcohols, C12-14 is 4.0 mg/l at 25 degC (experimental database).
Executive summary:

The ECOSAR QSAR model predicts that 14 -day LC50 value would to be 167.217 mg/L (ppm) for soil macroorganisms. Predicted to be non-toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.

The water solubility of the Alcohols, C12-14 is 4.0 mg/l at 25 degC (experimental database).

Endpoint:
toxicity to soil macroorganisms except arthropods: short-term
Type of information:
other: published data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to guideline
Guideline:
other: Verfahrensvorschlag Toxizitaetstest am Regenwurm Eisenia foetida (Savigny) 1826 in kuenstlichem Boden (USA, 14 Tage), Umweltbundesamt 3/1984.
Deviations:
not specified
GLP compliance:
not specified
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Eisenia fetida
Animal group:
annelids
Details on test organisms:
Details on test organisms
- Phylum: Annelida
- Family: Lumbricidae
Study type:
laboratory study
Substrate type:
artificial soil
Limit test:
no
Total exposure duration:
21 d
Reference substance (positive control):
not specified
Duration:
21 d
Dose descriptor:
EC0
Effect conc.:
> 1 000 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Validity criteria fulfilled:
not specified
Conclusions:
In the 21-day acute toxicity test no toxic effects on Eisenia foetida could be observed. EC0 was>1000 mg/kg soil dw
Executive summary:

In the 21-day acute toxicity test according to 'Verfahrensvorschlag Toxizitaetstest am Regenwurm Eisenia foetida (Savigny) 1826 in kuenstlichem Boden (USA, 14 Tage), Umweltbundesamt 3/1984' no toxic effects on Eisenia foetida could be observed.

Description of key information

In the 21-day acute toxicity test no toxic effects on Eisenia foetida could be observed. EC0 was>1000 mg/kg soil dw

Key value for chemical safety assessment

Short-term EC50 or LC50 for soil macroorganisms:
5 000 mg/kg soil dw
Long-term EC10, LC10 or NOEC for soil macroorganisms:
1 000 mg/kg soil dw

Additional information

In the 21-day acute toxicity test no toxic effects on Eisenia foetida could be observed. EC0 was>1000 mg/kg soil dw