Alcohols, C12-14

Toxicity to soil macroorganisms except arthropods

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

toxicity to soil macroorganisms except arthropods: long-term

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.

Qualifier:

according to guideline

Guideline:

other: QSAR

Principles of method if other than guideline:

ECOSAR Program (v1.00)

GLP compliance:

no

Remarks:

not applicable to QSAR models

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

other: earthworm

Animal group:

other: QSAR model

Study type:

other: QSAR

Substrate type:

other: QSAR

Limit test:

no

Total exposure duration:

14 d

Test temperature:

not applicable. QSAR model

pH:

not applicable. QSAR model

Moisture:

not applicable. QSAR model

Details on test conditions:

CAS Number:80206-82-2
SMILES : CCCCCCCCCCCCO
CHEM : Alcohols, C12-14
MOL FOR: C12 H26 O1
MOL WT : 186.34
Log Kow: 4.77 (KowWin estimate)
Wat Sol: 4 mg/L (experimental database)

Reference substance (positive control):

no

Duration:

14 d

Dose descriptor:

LC50

Effect conc.:

167.217 mg/kg soil ww

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: (Q)SAR prediction

Remarks on result:

other: non-toxic at the limit of solubility, as determined by (Q)SAR

Details on results:

LC50 (14-day, earthworm)= 167.217 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 167.217 mg/kg soil dw
The ECOSAR QSAR model predicts that 14 -day LC50 value would to be 136.108 mg/L (ppm) for soil macroorganisms. Predicted to be non-toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.
The water solubility of the Alcohols, C12-14 is 4.0 mg/l at 25 degC (experimental database).

Reported statistics and error estimates:

US EPA accepted QSAR method for chemicals properties assessment.

Overview of QSARs estimations on toxicity of 

Alcohols, C12-14

to soil macroorganisms

Method	Results	Remarks	Reference
QSAR estimate	LC50 (14-day, earthworm)= 167.217 mg/L (ppm)	Reliable withrestrictions, QSAR estimated data	ECOSAR Program (v1.00)

 

 

LC50 (14-day, earthworm)= 167.217 mg/kg soil dw

Validity criteria fulfilled:

yes

Remarks:

US EPA accepted QSAR method for chemicals properties assessment.

Conclusions:

LC50 (14-day, earthworm)= 167.217 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 167.217 mg/kg soil dw
The ECOSAR QSAR model predicts that 14 -day LC50 value would to be 167.217mg/L (ppm) for soil macroorganisms. Predicted to be non-toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.
The water solubility of the Alcohols, C12-14 is 4.0 mg/l at 25 degC (experimental database).

Executive summary:

The ECOSAR QSAR model predicts that 14 -day LC50 value would to be 167.217 mg/L (ppm) for soil macroorganisms. Predicted to be non-toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.

The water solubility of the Alcohols, C12-14 is 4.0 mg/l at 25 degC (experimental database).

Reference 2

Endpoint:

toxicity to soil macroorganisms except arthropods: short-term

Type of information:

other: published data

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

according to guideline

Guideline:

other: Verfahrensvorschlag Toxizitaetstest am Regenwurm Eisenia foetida (Savigny) 1826 in kuenstlichem Boden (USA, 14 Tage), Umweltbundesamt 3/1984.

Deviations:

not specified

GLP compliance:

not specified

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Eisenia fetida

Animal group:

annelids

Details on test organisms:

Details on test organisms
- Phylum: Annelida
- Family: Lumbricidae

Study type:

laboratory study

Substrate type:

artificial soil

Limit test:

no

Total exposure duration:

21 d

Reference substance (positive control):

not specified

Duration:

21 d

Dose descriptor:

EC0

Effect conc.:

> 1 000 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Validity criteria fulfilled:

not specified

Conclusions:

In the 21-day acute toxicity test no toxic effects on Eisenia foetida could be observed. EC0 was>1000 mg/kg soil dw

Executive summary:

In the 21-day acute toxicity test according to 'Verfahrensvorschlag Toxizitaetstest am Regenwurm Eisenia foetida (Savigny) 1826 in kuenstlichem Boden (USA, 14 Tage), Umweltbundesamt 3/1984' no toxic effects on Eisenia foetida could be observed.

Description of key information

In the 21-day acute toxicity test no toxic effects on Eisenia foetida could be observed. EC0 was>1000 mg/kg soil dw

Key value for chemical safety assessment

Short-term EC50 or LC50 for soil macroorganisms:

5 000 mg/kg soil dw

Long-term EC10, LC10 or NOEC for soil macroorganisms:

1 000 mg/kg soil dw

Additional information

In the 21-day acute toxicity test no toxic effects on Eisenia foetida could be observed. EC0 was>1000 mg/kg soil dw