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EC number: 279-420-3 | CAS number: 80206-82-2
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- ECOSAR Program (v1.00)
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- other: earthworm
- Animal group:
- other: QSAR model
- Study type:
- other: QSAR
- Substrate type:
- other: QSAR
- Limit test:
- no
- Total exposure duration:
- 14 d
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Moisture:
- not applicable. QSAR model
- Details on test conditions:
- CAS Number:80206-82-2
SMILES : CCCCCCCCCCCCO
CHEM : Alcohols, C12-14
MOL FOR: C12 H26 O1
MOL WT : 186.34
Log Kow: 4.77 (KowWin estimate)
Wat Sol: 4 mg/L (experimental database) - Reference substance (positive control):
- no
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 167.217 mg/kg soil ww
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: (Q)SAR prediction
- Remarks on result:
- other: non-toxic at the limit of solubility, as determined by (Q)SAR
- Details on results:
- LC50 (14-day, earthworm)= 167.217 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 167.217 mg/kg soil dw
The ECOSAR QSAR model predicts that 14 -day LC50 value would to be 136.108 mg/L (ppm) for soil macroorganisms. Predicted to be non-toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.
The water solubility of the Alcohols, C12-14 is 4.0 mg/l at 25 degC (experimental database). - Reported statistics and error estimates:
- US EPA accepted QSAR method for chemicals properties assessment.
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- LC50 (14-day, earthworm)= 167.217 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 167.217 mg/kg soil dw
The ECOSAR QSAR model predicts that 14 -day LC50 value would to be 167.217mg/L (ppm) for soil macroorganisms. Predicted to be non-toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.
The water solubility of the Alcohols, C12-14 is 4.0 mg/l at 25 degC (experimental database). - Executive summary:
The ECOSAR QSAR model predicts that 14 -day LC50 value would to be 167.217 mg/L (ppm) for soil macroorganisms. Predicted to be non-toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.
The water solubility of the Alcohols, C12-14 is 4.0 mg/l at 25 degC (experimental database).
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- other: published data
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: Verfahrensvorschlag Toxizitaetstest am Regenwurm Eisenia foetida (Savigny) 1826 in kuenstlichem Boden (USA, 14 Tage), Umweltbundesamt 3/1984.
- Deviations:
- not specified
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- Details on test organisms
- Phylum: Annelida
- Family: Lumbricidae - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- no
- Total exposure duration:
- 21 d
- Reference substance (positive control):
- not specified
- Duration:
- 21 d
- Dose descriptor:
- EC0
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In the 21-day acute toxicity test no toxic effects on Eisenia foetida could be observed. EC0 was>1000 mg/kg soil dw
- Executive summary:
In the 21-day acute toxicity test according to 'Verfahrensvorschlag Toxizitaetstest am Regenwurm Eisenia foetida (Savigny) 1826 in kuenstlichem Boden (USA, 14 Tage), Umweltbundesamt 3/1984' no toxic effects on Eisenia foetida could be observed.
Referenceopen allclose all
Overview of QSARs estimations on toxicity of
Alcohols, C12-14
to soil macroorganismsMethod
|
Results |
Remarks |
Reference |
QSAR estimate |
LC50 (14-day, earthworm)= 167.217 mg/L (ppm)
|
Reliable withrestrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
LC50 (14-day, earthworm)= 167.217 mg/kg soil dw
Description of key information
In the 21-day acute toxicity test no toxic effects on Eisenia foetida could be observed. EC0 was>1000 mg/kg soil dw
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 5 000 mg/kg soil dw
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 1 000 mg/kg soil dw
Additional information
In the 21-day acute toxicity test no toxic effects on Eisenia foetida could be observed. EC0 was>1000 mg/kg soil dw
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