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EC number: 279-420-3 | CAS number: 80206-82-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Draize Test
- GLP compliance:
- yes
Test material
- Reference substance name:
- Alcohols, C12-14
- EC Number:
- 279-420-3
- EC Name:
- Alcohols, C12-14
- Cas Number:
- 80206-82-2
- Molecular formula:
- C13H28O
- IUPAC Name:
- Alcohols, C12-14
- Details on test material:
- - Name of test material (as cited in study report)Tradename Lorol Spezial type 70 C12-14 alcohols Type AType A. 100% Linear; >90% C12/14 (C12>14), <10% C16 [range C6-C18];
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TTEST ANIMALS:
-Rabbit
- Strain: New Zealand White
- Sex: Male
- Source: Not reported
- Age: Not reported
- Weight at study initiation: Not reported
- Number of animals: 6
- Controls: The untreated eye served as a control.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 24 hours
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- ADMINISTRATION/EXPOSURE
- Preparation of test substance: Undiluted
- Amount of substance instilled: 0.1 ml
- Vehicle: none
- Postexposure period: 24 hours
- Controls: The untreated eye served as a control.
EXAMINATIONS
- Ophthalmoscopic examination: Not reported.
- Scoring system: Draize
- Observation period: 24 hours
- Tool used to assess score: Not reported.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hrs
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks:
- Fully reversible by 24 hours after instillation.
- Remarks on result:
- other: not rinsed. Draize scoring up to 24 hours post instillation. There was no involvement of the cornea or iris. Minimal conjunctival redness was noted (score <1) at 2 and 6 hours after instillation. All scores at 24 hours were 0.
- Irritant / corrosive response data:
- Draize scoring up to 24 hours post instillation. There was no involvement of the cornea or iris. Minimal conjunctival redness was noted (score <1) at 2 and 6 hours after instillation. All scores at 24 hours were 0.
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- This C12-14 alcohol is not irritating to the eye when applied undiluted.
Result: not irritating . - Executive summary:
This C12-14 alcohol is not irritating to the eye when applied undiluted.
Result: not irritating .
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