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EC number: 204-340-2 | CAS number: 119-64-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984-11-13 to 1984-11-19
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2,3,4-tetrahydronaphthalene
- EC Number:
- 204-340-2
- EC Name:
- 1,2,3,4-tetrahydronaphthalene
- Cas Number:
- 119-64-2
- Molecular formula:
- C10H12
- IUPAC Name:
- 1,2,3,4-tetrahydronaphthalene
- Details on test material:
- Produced by Hüls AG, purity > 98 %, main impurities naphthalene and decahydronaphthtalene
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Small white Russian, Chbb-SPF
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS:
- Strain: Small white Russian, Chbb-SPF
- Sex: male and female
- Source: Dr. Karl Thomae GmbH, Biberach
- Weight at study initiation: 2.2-2.7 kg
- Number of animals: 3 males, 3 females
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- - undiluted
- Amount applied: 0.1 ml
- Controls: untreated (left) eye - Duration of treatment / exposure:
- not rinsed
- Observation period (in vivo):
- Ophtalmoscopic examination: 1, 24, 48, 72 hours, 6 days after treatment
- Number of animals or in vitro replicates:
- 6
- Details on study design:
-
EXAMINATIONS
- Ophtalmoscopic examination: 1, 24, 48, 72 hours, 6 days after treatment
- Scoring system: Draize (1959); Appendix VI of 79/831/EEC
- Tool used to assess score: Na fluorescein / ophthalmic lamp / visual inspections
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 5.17
- Max. score:
- 110
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24,48, 72 h
- Score:
- 0
- Max. score:
- 80
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 10
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 1.33
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0.22
- Reversibility:
- fully reversible within: 48 h
Applicant's summary and conclusion
- Conclusions:
- The rabbits In the study showed only slight to mild but also reversible conjunctival effects. Tetrahydronaphthalene was not considered to be an eye irritant.
- Executive summary:
In a primary eye irritation study 0.1 mL of undiluted tetrahydronaphthalene was instilled into the conjunctival sac of one eye of three male and three female young adult White Russian rabbits. Eyes were not rinsed. Animals were observed for 6 days.
Cornea and iris were not affected. Slight to mild and reversible conjunctival effects were observed. In this study, tetrahydronaphthalene was not an eye irritant.
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