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Diss Factsheets

Administrative data

Endpoint:
additional toxicological information
Type of information:
other: review
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Aceeptable, well documented publication

Data source

Reference
Reference Type:
review article or handbook
Title:
Lathyrism: A Neurotoxic Disease
Author:
Spencer P.S. and Schaumburg H.H.
Year:
1983
Bibliographic source:
Neurobehavioral Toxcicol. and Teratol., 5, 625-629 (1983)

Materials and methods

Type of study / information:
Review
Principles of method if other than guideline:
Review about the neurotoxic disease lathyrism and the causing agents.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-dimethylaminopropiononitrile
EC Number:
217-090-4
EC Name:
3-dimethylaminopropiononitrile
Cas Number:
1738-25-6
Molecular formula:
C5H10N2
IUPAC Name:
3-(dimethylamino)propanenitrile

Results and discussion

Any other information on results incl. tables

There is no known relationship between lathyrism (caused by
excessive consumption of Lathyrus sativus) and the
neurodegenerative conditions associated with compounds like
beta-aminopropionitrile (contained in L. sativus), beta,
beta´-iminodipropionitrile and 3-dimethylaminopropionitrile
(both not contained in L. sativus).

Applicant's summary and conclusion

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