3-dimethylaminopropiononitrile

Endpoint summary

Description of key information

3-dimethylaminopropionitrile is non irritating to the skin. The substans did cause minimal erythema and non edema. However a transient smeary layer were observed on the surface of the eyes was observed after treatment . Therfore 3-dimethylaminopropionitrile has to be regarded as slightly to moderatly  irritating to the eyes.
Respiratory system
no data

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Additional information

There are sufficient data available to assess the potential for skin and eye irritation of 3-dimethylaminopropionitrile.

Skin

The relevant study meets scientific standards with acceptable restrictions (limited documentation; BASF 1975). Skin irritation was tested using an internal standard method (BASF test). White Vienna rabbits were used. Two animals were treated for 1, 5 and 15 minutes and 2 other animals for 20 hours using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with the test substance. Exposure for 20 h caused no edema and only slight erythema (mean score 0.5 for the readings after 24, 48 and 72h) which were reversible within 4 d. Exposure for one, five or 15 min caused neither erythema nor edema.

A second in vivo study result with very limited information on the study method and an incompatible scoring system was available from literature (10 grade ordinal series; Smyth et al. 1962). However, grade 1 indicates that the test substance did not cause any reaction from undiluted test samples after presumably 24 h. A study result from a secondary source indicate mild skin irritation without any further information (Marhold 1986, cited in RTECS). Since reading points, individual scores and reversibility are not clear, the test result is considered as irrelevant.

Eye

The relevant study is comparable to OECD Guideline 405 with acceptable restrictions (partly limited documentation; 50 µl instead of 100 µl test substance instilled; BASF 1975). The study is however sufficient for evaluation of this endpoint. The substance was applied unchanged into the eyes of two Vienna White rabbits and was not washed out. Corneal opacity and conjunctivae redness (mean score 1.5 for the readings after 24, 48 and 72h in both parameters) were reversible within 8 days. Iritis and chemosis were not observed.

A second in vivo study result with very limited information on the study method and an incompatible scoring system indicating severe effects was reported in Literature ( grade 5; Smyth et al. 1962). Additionally, a study result from a secondary source indicates a moderate potential for eye irritation without any further information (Marhold 1986/RTECS). However, reading points, individual scores and reversibility are not clear in both studies and therefore the test results are considered as irrelevant.

Effects on eye irritation: slightly irritating

Justification for classification or non-classification

Skin

3-dimethylaminopropionitrile has not to be classified as skin irritant following EU and GHS requirements, respectively.

Eye

3-dimethylaminopropionitrile has not to be classified as eye irritant following EU. According to GHS 3-dimethylaminopropionitrile is a mild eye irritant (Cat.2B).

Respiratory system

No relevant data available. Due to the slight effects on mucous membranes 3-dimethylaminopropionitrile is not supposed to be a respiatory irritant.