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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Additional information

No reliable information is available according to animal data.

Human data: In 1978, beside neurotoxic effects also sexual dysfunction was observed in workers in two plants processing ESN-NIAX katalysator (95% DMPAN) in Polyorethanproduction in the(Keogh 1983). Impotence and decreased libido were found to be promptly reversible symptoms in most of the cases. However, after two years still symptoms of sexual dysfunction were observed.

In contrast, neither neurotoxic nor sexual dysfunction symptoms were observed in an examination of a German plant processing DMAPN (Deckert et al. 1982). 34 examined workers were exposed to DMAPN for over 9 years in mean to maximum air concentrations of 0.007 to 0.024 ppm during the study; the former exposure levels are, however, considered higher.


Short description of key information:
No information from animal studies is available. An effect on reproduction (Impotence and decreased libido) can not be excluded completely at high concentrations. These effects were reversible and only seen at mixed exposure at polyurethan production. No such effect were reported for exposure up to 0.024 ppm at a DMPAN production site in a controlled occupational medical suveillance.

Effects on developmental toxicity

Description of key information
No embryotoxicity was observed in an orientating screening reprotoxicity study with 2 pragnant female rat 
Effect on developmental toxicity: via oral route
Dose descriptor:
NOAEL
200 mg/kg bw/day
Additional information

In an orientating screening reprotoxicity study 2 female rat recieved dimethylpropionitril via there feed during pragnancy (0.3 %). This equals about 200 mg/kg bw. No embryotoxicity was observed. But due to the low animal number the result is not robust.

However the metabolite ß aminopropionitril was ebpriotoxic in the same study (Stamler, 1995). There may be an important influence by toxicokinetic.

Justification for classification or non-classification

Availiable data is not sufficient for classification but partly inconclusive.

Additional information