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Administrative data

Description of key information

Acute oral toxicity: LD50 = 27 mg/kg bw (mouse, rat)
Acute dermal toxicity: LD50 = 18-60 mg/kg bw (rabbit)
Acute inhalation toxicity: LC50 = between 0.054 and 0.52 mg/L (rat)

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: review article which gives not sufficient information on experimental details
Reason / purpose for cross-reference:
reference to same study
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
other: no data
Limit test:
no
Specific details on test material used for the study:
no data
Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data
Preliminary study:
no data
Sex:
not specified
Dose descriptor:
LD50
Effect level:
27 mg/kg bw
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data
Interpretation of results:
Category 2 based on GHS criteria
Conclusions:
Although lacking methodological details, the data given support the classification as Toxic Class 2 according to OECD GHS.
Executive summary:

Although lacking methodological details, the given data support the classification as Toxic Class 2 according to OECD GHS, since the LD50 (mouse oral) was reported to be 27 mg/kg bw.

Endpoint:
acute toxicity: oral
Type of information:
other: review article
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Study shows significant methological deficiencies (no LD50 determination)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
: <5 animals per dose group, non data on feeding/housing, inappropriate dose levels, no LD50 calculated, no pathology/necropsy performed
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
40, 42, 44, 45, 46, 48, 60 mg/kg BW
No. of animals per sex per dose:
2-8 animals per dose group
Control animals:
not specified
Details on study design:
no data
Statistics:
no data
Preliminary study:
no data
Sex:
not specified
Dose descriptor:
LD50
Effect level:
42 mg/kg bw
Remarks on result:
other: assessed from given data
Sex:
not specified
Dose descriptor:
LD0
Effect level:
40 mg/kg bw
Mortality:
see Table 1 below
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Table 1: The effect of oral administration of sodium azide in rats:

Number of rats

Dose [mg/kg BW]

Died in 3 hours

Mortality [%]

3

40

0

0

2

42

1

50

2

44

1

50

8

45

5

62

3

46

3

100

3

48

3

100

3

60

3

100

Interpretation of results:
Category 2 based on GHS criteria
Conclusions:
From the available data, the LD50 (rat, oral) can be estimated to be 42 mg/kg bw, which is consistent with categorization into OECD GHS toxicity class 2.
Executive summary:

Fairhall examined the acute oral toxicity of sodium azide in rats. They observed that in the dose groups 42 and 44 mg/kg, 50% of the animals died within 3 hours after administration, which gives an indication of the LD50 (rat, oral) to be in the range 42 mg/kg bw although inadequate dose levels were selected for this study. This value is consistent with categorization into OECD GHS toxicity class 2, characterized by a LD50 (oral) of 5-50 mg/kg bw.

Endpoint:
acute toxicity: oral
Type of information:
other: review article
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: review article which gives not sufficient information on experimental details
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no
Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data
Preliminary study:
no data
Sex:
not specified
Dose descriptor:
LD50
Effect level:
37.4 mg/kg bw
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data
Interpretation of results:
Category 2 based on GHS criteria
Conclusions:
From the available data, the LD50 (mouse, oral) can be estimated to be <50 mg/kg bw, which is consistent with OECD GHS toxicity class 2.
Executive summary:

From the available data, the LD50 (mouse, oral) can be estimated to be <50 mg/kg bw, which is consistent with OECD GHS toxicity class 2.

Endpoint:
acute toxicity: oral
Type of information:
other: handbook data
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
other: no data
Limit test:
no
Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data
Preliminary study:
no data
Sex:
not specified
Dose descriptor:
LD50
Effect level:
10 mg/kg bw
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data
Interpretation of results:
Category 2 based on GHS criteria
Conclusions:
The LD50 (rabbit, oral) was reported to be 10 mg/kg bw, which categorizes sodium azide into OECD GHS toxicity class 2 (5 - 50 mg/kg bw).
Executive summary:

The LD50 (rabbit, oral) was reported to be 10 mg/kg bw, which categorizes sodium azide into OECD GHS toxicity class 2 (5 - 50 mg/kg bw).

Endpoint:
acute toxicity: oral
Type of information:
other: handbook data
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
other: no data
Limit test:
no
Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data
Preliminary study:
no data
Sex:
not specified
Dose descriptor:
LD50
Effect level:
27 mg/kg bw
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 35.9 - <= 70.9 mg/kg bw
Remarks on result:
other: when applied in a granular form, containing 8 - 16% sodium azide
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data
Interpretation of results:
Category 2 based on GHS criteria
Conclusions:
The LD50 (rat, oral) for sodium azide was reported to be 27 mg/kg bw. When applied in a granular preparation containing 8 and 16% sodium azide the LD50 was 786 and 443 mg/kg bw, respectively, corresponding to a sodium azide concentration of 63 -71 mg/kg bw.
Executive summary:

The LD50 (rat, oral) for sodium azide was reported to be 27 mg/kg bw. When applied in a granular preparation containing 8 and 16% sodium azide the LD50 was 786 and 443 mg/kg bw, respectively, corresponding to a sodium azide concentration of 63 -71 mg/kg bw.

Under the given concentrations and the assumption that sodium azide in a granular preparation has a poorer bioavailability, resulting in a higher LD50, sodium azide must be categorized into OECD GHS toxicity class 2 (5 - 50 mg/kg bw).

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
27 mg/kg bw
Quality of whole database:
Weight of evidence

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008-05-16 to 2009-12-02
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EPA OPPTS 870.1300 (Acute inhalation toxicity)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes
Test type:
traditional method
Limit test:
no
Specific details on test material used for the study:
- Lot: #C-07A005 and #C-08V701
- Composition: >95% pure
- Physical appearance: White solid, similar in appearance to typical table salt
- pH: 9+
- Solubility: Soluble in water
- Stability: Test substance was expected to be stable for the duration of testing
- Expiration Date: Not Applicable
- Treatment of the test material prior testing: Prior to aerosolization, the test substance was ground in a ball mill for 24 hours and then further ground in a coffee mill (Cuisinart, Model #DC0-20) until it passed through a 425 micrometer sieve (USA standard).
Species:
rat
Strain:
Sprague-Dawley
Remarks:
albino
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Ace Animals, Inc., Boyertown, PA
- Females (if applicable) nulliparous and non-pregnant: Yes
- Age at study initiation: Young adult (9-10 weeks) /
- Weight at study initiation: males 280-338 grams and females 190-236
- Housing: The animals were singly housed in suspended stainless steel caging with mesh floors. Litter paper was placed beneath the cage and was changed at least three times per week.
- Diet: Purina Rodent Chow #5012
- Water (e.g. ad libitum): Yes
- Acclimation period: 14-18 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-24°C
- Humidity (%): 66-79%
- Photoperiod (hrs dark / hrs light): 12 / 12
Route of administration:
inhalation: dust
Type of inhalation exposure:
nose only
Vehicle:
air
Mass median aerodynamic diameter (MMAD):
> 3.5 - < 3.7 µm
Geometric standard deviation (GSD):
> 1.88 - < 2.16
Remark on MMAD/GSD:
The aerodynamic mass median diameter and geometric standard deviation were determined graphically using two-cycle logarithmic probit axes.
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Mini-Nose Only Inhalation Chamber by ADG Developments LTD
- Exposure chamber volume: 6. 7 L
- Method of holding animals in test chamber: Polycarbonate holding tubes which seal to the chamber with an "O" ring during exposure.
- Source of air: Air compressor by JUN-AIR
- System of generating particulates/aerosols: Wright Dust Generator driven by a variable speed motor by Dayton
- Method of particle size determination: Eight-stage Andersen cascade impactor

TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: An eight-stage Andersen cascade impactor was used to assess the particle size distribution of the test atmosphere. Samples were withdrawn from the breathing zone of the animals at two intervals. The filter paper collection stages were weighed before and after sampling to determine the mass collected upon each stage.
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): The aerodynamic mass median diameter and geometric standard deviation were determined graphically using two-cycle logarithmic probit axes. See table 1 under "Any other information on materials and methods incl. tables"
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
See table 1 under "Any other information on materials and methods incl. tables"
No. of animals per sex per dose:
5 males and 5 females per dose/ 3 doses
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of weighing: Prior to exposure and again on Days 7 and 14 or after death
- Frequency of observation: At least once daily for up to 14 days following exposure or until death occured
- Necropsy of survivors performed: yes
- Examinations performed: mortality, signs of toxicity, behavioral changes, body weight
Statistics:
Mean + / - Standard Deviation
Preliminary study:
See table 1 under "Any other information on materials and methods incl. tables"
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 0.054 - < 0.52 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Mortality:
- At 2.02 mg/L exposure level, all animals died within 190 minutes of exposure to the test atmosphere
- At 0.52 mg/L exposure level, four male and four female rats died during exposure to the test atmosphere
- At 0.0542 mg/L exposure level, no mortality was observed
Clinical signs:
other: - At 0.52 mg/L exposure level, the surviving animals were hypoactive and exhibited hunched posture, abnormal respiration and nasal discharge - At 0.0542 mg/L exposure level, all animals exhibited ocular and nasal discharge.
Body weight:
- At 0.52 mg/L exposure level, all surviving animals recovered by Day 3, gained body weight and appeared active and healthy for the remainder 14-day observation period.
- At 0.0542 mg/L exposure level, body weight was shown to increase over the observation period
Gross pathology:
- At 2.02 mg/L exposure level, gross necropsy of the decedents revealed red, edematous lungs, normal trachea and clear wet nasal discharge.
- At 0.52 mg/L exposure level, gross necropsy of the decedents revealed red, edematous lungs, normal trachea and clear wet nasal discharge. No gross abnormalities were noted for the euthanized animal when necropsied at the conclusion of the 14-day observation period.
- At 0.0542 mg/L exposure level, no gross abnormalities were observed
Interpretation of results:
Category 2 based on GHS criteria
Conclusions:
In conclusion, the acute inhalation toxicity of Sodium azide, as determined in a study according to EPA guideline OPPTS 870.1300, lies between an LC50 (4 h) of 0.054 and 0.52 mg /L in male and female rats.
Executive summary:

In an acute inhalation toxicity study according to EPA guideline OPPTS 870.1300, groups of young adult Sprague Dawley rats (5/sex) were exposed at test concentrations of 0.054, 0.52 and 2 mg/L via the inhalation route (nose only) to Sodium azide (>95% purity) in compressed air for 4 hours. After exposure, the animals were observed for a period of 14 days. At test concentration of 0.52 and 2.0 mg/L, mortality was observed. An increase in body weight was seen at 0.54 mg/L and gross pathology at test concentrations 0.52 and 2 mg/L revealed red, edematous lungs, normal trachea and clear wet nasal discharge. Thus, under the conditions of this study, the single exposure acute inhalation LC50 of the test substance is between 0.054 and 0.52 mg/L in male and female rats.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LC50
Value:
54 mg/m³
Quality of whole database:
Guideline study

Acute toxicity: via dermal route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: dermal
Type of information:
other: handbook data
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Handbook data lacking methological details.
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
other: not reported
Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data
Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
no data
Duration of exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data
Preliminary study:
no data
Sex:
not specified
Dose descriptor:
LD50
Effect level:
20 mg/kg bw
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data
Interpretation of results:
Category 1 based on GHS criteria
Conclusions:
A dermal LD50 of 20 mg/kg bw sodium azide has been reported for rabbit.
Executive summary:

A dermal LD50 of 20 mg/kg bw sodium azide has been reported for rabbit. According to the OECD GHS, this value would categorize sodium azide into toxicity category 1.

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Unsuitable test system
Qualifier:
according to guideline
Guideline:
other: OECD guideline 404 (acute dermal irritation/corrosion)
Deviations:
yes
Remarks:
1 and 4h exposure
GLP compliance:
not specified
Test type:
fixed dose procedure
Species:
rabbit
Strain:
other: New Zealand, unspecified
Sex:
male/female
Type of coverage:
other: semi-occlusive & occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
4 h
Doses:
0.5 g
No. of animals per sex per dose:
6 animals per dose
Control animals:
not specified
Sex:
male/female
Dose descriptor:
LD50
Effect level:
>= 500 - <= 1 000 mg/kg bw
Remarks on result:
other: Estimation from given data (animal weight 2-4kg, applicated dose 4 x 0.5g per animal)
Mortality:
3 animals were found dead after 1 hour exposure
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
In a dermal irritation study according to OECD 404, three of six animals exposed to 4 x 0.5 g of Sodium azide died 1 h / 4 h treatment. As the weight of the rabbits was 2-4 kg, the LD50(rabbit, dermal) can be estimated to range between 500 - 1000 mg/kg bw.
Executive summary:

Using a defined method for the determination of irritant and corrosive effects (OECD 404, 1981), the effects of varying the exposure time and the extent of occlusion were investigated and compared in rabbit skin experiments (by occlusive and semi-occlusive methods, each at exposure times of 1 hr and 4 hr). Results showed that, independent from treatment, three of six animals of each group were found dead after dermal exposure to 4 x 0.5g of sodium azide. As the weight of the rabbits was 2-4 kg, the LD50(rabbit, dermal) can be estimated to range between 500 - 1000 mg/kg bw.

The benchmarks for toxicity categorization according to GHS are acute toxicity estimates (LD50) of 201-1000 (toxicity category III) which is covered by the estimated LD50.

Endpoint:
acute toxicity: dermal
Type of information:
other: data collection
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Principles of method if other than guideline:
No method description provided
GLP compliance:
not specified
Test type:
other: not specified
Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data
Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
no data
Duration of exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data
Preliminary study:
no data
Sex:
not specified
Dose descriptor:
other: LD
Effect level:
>= 18 - <= 60 mg/kg bw
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data
Interpretation of results:
study cannot be used for classification
Conclusions:
In the data collection published by the Scientific Committee for Occupational Exposure Limits (SCOEL), LD values (rabbit dermal) of 18-60 mg/kg bw are reported.
Executive summary:

In the data collection published by the Scientific Committee for Occupational Exposure Limits (SCOEL), LD values (rabbit dermal) of 18-60 mg/kg bw are reported, based on two studies conducted by Bassendowska et al. (Medycyna Pracy 1961, 12: 427-42 and Medycyna Pracy 1965, 16: 187-99). The test conditions are not mentioned in the SCOEL publication.

Endpoint:
acute toxicity: dermal
Type of information:
other: handbook data
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Handbook data lacking methological details
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
other: not specified
Species:
rabbit
Strain:
other: albino
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data
Type of coverage:
not specified
Vehicle:
other: granular formulation containing 8-16% sodium azide
Details on dermal exposure:
no data
Duration of exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data
Preliminary study:
no data
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 118 - <= 600 mg/kg bw
Remarks on result:
other: applicated as granular formulation containing 8 - 16% sodium azide
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 19 - <= 48 mg/kg bw
Remarks on result:
other: calculated sodium azide concentration in the granular formulation containing 8 - 16% sodium azide
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data
Interpretation of results:
Category 1 based on GHS criteria
Conclusions:
The acute dermal LD50 (rabbit dermal) of a granular formulation containing 8 and 16% Sodium azide was reported to be 600 and 118 mg/kg bw, corresponding to a concentration of 48 and 19 mg/kg of pure Sodium azide.
Executive summary:

The acute dermal LD50 (rabbit dermal) of a granular formulation containing 8 and 16% Sodium azide was reported to be 600 and 118 mg/kg bw, corresponding to a concentration of 48 and 19 mg/kg of pure Sodium azide.

This categorizes sodium azide into OECD GHS toxicity category 1 (0 - 50 mg/kg dermal).

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
18 mg/kg bw
Quality of whole database:
Weight of evidence

Additional information

Acute oral toxicity:

In the literature, four LD50 values for acute oral toxicity in rodents (mouse, rat) in the range of 27-42 mg/kg bw were reported. As the four reports are quite consistent and using a conservative benchmark, the lowest value of 27 mg/kg bw (which was observed in 2 different species) can be used as key parameter. Furthermore, the results of a 14d study on rats which died at day 2 after ingestion of ≥20 mg/kg bw strengthen the reported values. Rabbits seem to be more sensitive towards Sodium azide than rodents as one entry mentiones a LD50 (rabbit, oral) of 10 mg/kg bw. As the reliability of this study cannot be assessed because no methodological details were given and the other four entries are for the most part consistent, the value 27 mg/kg bw was chosen as key parameter.

 

Acute inhalation toxicity:

The only available study on acute inhalation toxicity was that of Durando (2009), who exposed rats via nose-only inhalation route to vapour of Sodium azide for 4 hours. At test concentration of 0.52 and 2.0 mg/L, mortality was observed. An increase in body weight was seen at 0.54 mg/L and gross pathology at test concentrations 0.52 and 2 mg/L revealed red, edematous lungs, normal trachea and clear wet nasal discharge. Thus, under the conditions of this study, the single exposure acute inhalation LC50 of the test substance is between 0.054 and 0.52 mg/L in male and female rats. 

 

Acute dermal toxicity:

Four different studies were available focussing on dermal toxicity of which three give consistent results of LD50 (rat, dermal) = 18-60 mg/kg bw although these data are not experimentally assessed by the authors but only cited from other sources which were to date not available. The fourth value, estimated from the study of Potokar et al. (1985) is derived from a skin corrosion/irritation experiment in which 3 of 6 rabbits died after application of 500-1000 mg/kg bw Sodium azide to their skin.

 

Study

Species

Marker

Oral toxicity

Fairhall 1943

Rat

LD50 = 42 mg/kg bw

WSSA

Rat

LD50 = 27 mg/kg bw

Graham 1949

Mouse

LD50 = 27 mg/kg bw

Gregory 1978

Mouse

LD50 = 37.4 mg/kg bw

WSSA

Rabbit

LD50 = 10 mg/kg bw

Inhalation toxicity

Durando J.

Rat

LC50 = between 0.054 and 0.52 mg/L

Dermal toxicity

ACGIH 1991

Rabbit

LD50 = 20 mg/kg bw

Potokar 1985

Rabbit

LD50 = 500-1000 mg/kg bw

SCOEL 2008

Rabbit

LD50 = 18-60 mg/kg bw

WSSA 1983

Rabbit

LD50 = 19-48 mg/kg bw

 

Justification for classification or non-classification

Acute oral toxicity:

All five studies report LD50 values for rodents or rabbit in the concentration range 10-42 mg/kg bw, which allows categorization into OECD GHS toxicity category II (H300), ranging from 5-50 mg/kg bw.

The labelling requires the skull and crossbones symbol together with the signal word “Danger” and the hazard statement “Fatal if swallowed”.

 

Acute dermal toxicity:

Two different sources report LD50 values for rabbits in the concentration range 18-48 mg/kg bw, which allows categorization into OECD GHS toxicity category I (H310), ranging from 0-50 mg/kg bw. Another report slightly exceeds this benchmark, reporting a dermal toxicity of 18-60 mg/kg bw but using a conservative apporoach, the classification as GHS toxicity category I seems justified.

The labelling requires the skull and crossbones symbol together with the signal word “Danger” and the hazard statement “Fatal in contact with skin”.

 

Acute inhalation toxicity:

The available study leads to a LC50 (rat, inhalation) between 0.054 and 0.52 mg/L for Sodium azide. Based on this study, Sodium azide has to be classified as OECD GHS toxicity category II (H330), ranging from 0.05 to 0.5 mg/L for dusts.