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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
The toxicity of lead azide
Author:
Fairhall L.T. et al.
Year:
1943
Bibliographic source:
Public health reports (1896-1970). 58(15): 607-17
Reference Type:
review article or handbook
Title:
Information profile sodium azide
Author:
Gregory A.R.
Year:
1978
Bibliographic source:
NIOSH / DCDSD

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium azide
EC Number:
247-852-1
EC Name:
Sodium azide
Cas Number:
26628-22-8
Molecular formula:
N3Na
IUPAC Name:
sodium azide

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
25, 30, 33, 35, 36, 37 mg/kg bw
No. of animals per sex per dose:
4-15
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 33.4 mg/kg bw
Remarks on result:
other: calculated from the published data
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data

Any other information on results incl. tables

Number of rats

Dose [mg/kg bw]

Died in 3h

Mortality [%]

4

25

0

0

11

30

1

10

12

33

8

66

15

35

10

66

5

36

4

80

5

37

5

100

Considering the value (33 mg/kg / 66% mortality) as outlier, a nearly linear dose-response relationship (slope: 12.50, y-axis intercept -367.22, R2=0.9902) can be obtained in the interval 30-37 mg/kg.

Using this linear regression, the LD50 (rat, i.p.) was calculated to be 33.4 mg/kg bw.

Applicant's summary and conclusion

Conclusions:
From the availabla data, an LD50 (rat, i.p.) of 33.4 mg/kg bw can be calculated.
Executive summary:

Fairhall et al. examined the toxicity of sodium azide after intraperitoneal (i.p.) administration to rats. The results show a nearly linear dose-response relationship in the range 30-37 mg/kg with the value 33 mg/kg considered as outlier. By linear regression of the remaining values, an LD50 (rat i.p.) of 33.4 mg/kg bw can be calculated.