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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: review article which gives not sufficient information on experimental details
Cross-reference
Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
acute toxicity: other routes
Type of information:
other: review article
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: review article which gives not sufficient information on experimental details
Principles of method if other than guideline:
no data
GLP compliance:
no
Limit test:
no
Species:
mouse
Strain:
not specified
Sex:
not specified
Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 28 - < 34 mg/kg bw
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Conclusions:
In this study, the LD50 (mouse, i.p.) was reported to be 28-34 mg/kg bw.
Executive summary:

In an acute intraperitoneal toxicity study, mice were given a dose of Sodium azide.

The LD50 (mouse i.p.) was reported to be 28 -34 mg/kg bw.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Actions of sodium azide
Author:
Graham J.D.P.
Year:
1949
Bibliographic source:
Br J Pharmacol Chemother. 4(1):1-6, PMID: 18113147
Reference Type:
review article or handbook
Title:
Information profile sodium azide
Author:
Gregory A.R.
Year:
1978
Bibliographic source:
NIOSH / DCDSD
Reference Type:
review article or handbook
Title:
Recommendation from the Scientific Committee on Occupational Exposure Limits (SCOEL) for Sodium Azide
Year:
2008
Bibliographic source:
European Commission: Scientific Committee on Occupational Exposure Limits (SCOEL)

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
other: no data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium azide
EC Number:
247-852-1
EC Name:
Sodium azide
Cas Number:
26628-22-8
Molecular formula:
N3Na
IUPAC Name:
sodium azide
Specific details on test material used for the study:
no data

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data

Results and discussion

Preliminary study:
no data
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
27 mg/kg bw
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Interpretation of results:
Category 2 based on GHS criteria
Conclusions:
Although lacking methodological details, the data given support the classification as Toxic Class 2 according to OECD GHS.
Executive summary:

Although lacking methodological details, the given data support the classification as Toxic Class 2 according to OECD GHS, since the LD50 (mouse oral) was reported to be 27 mg/kg bw.