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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
review article which gives not sufficient information on experimental details
Cross-reference
Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Principles of method if other than guideline:
no data
GLP compliance:
no
Limit test:
no
Species:
mouse
Strain:
not specified
Sex:
not specified
Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 28 - < 34 mg/kg bw
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Conclusions:
In this study, the LD50 (mouse, i.p.) was reported to be 28-34 mg/kg bw.
Executive summary:

In an acute intraperitoneal toxicity study, mice were given a dose of sodium azide. The LD50 (mouse i.p.) was reported to be 28-34 mg/kg bw.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Actions of sodium azide
Author:
Graham J.D.P.
Year:
1949
Bibliographic source:
Br J Pharmacol Chemother. 4(1):1-6, PMID: 18113147
Reference Type:
review article or handbook
Title:
Information profile sodium azide
Author:
Gregory A.R.
Year:
1978
Bibliographic source:
NIOSH / DCDSD
Reference Type:
review article or handbook
Title:
Recommendation from the Scientific Committee on Occupational Exposure Limits (SCOEL) for Sodium Azide
Year:
2008
Bibliographic source:
European Commission: Scientific Committee on Occupational Exposure Limits (SCOEL)

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
other: no data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium azide
EC Number:
247-852-1
EC Name:
Sodium azide
Cas Number:
26628-22-8
Molecular formula:
N3Na
IUPAC Name:
sodium azide
Specific details on test material used for the study:
no data

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data

Results and discussion

Preliminary study:
no data
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
27 mg/kg bw
Mortality:
no data
Clinical signs:
other: no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Interpretation of results:
Category 2 based on GHS criteria
Conclusions:
Although lacking methodological details, the LD50 (mouse oral) was reported to be 27 mg/kg bw.
Executive summary:

 In an acute oral toxicity study cited in a review article, mice were given a single oral dose of sodium azide (dose levels not specified). Although lacking methodological details, the LD50 (mouse oral) was reported to be 27 mg/kg bw. Applying the Globally Harmonised Classification System, the given data support the classification as Category 2 (LD50 > 5 to 50 mg/kg bw) or as Acute Tox. 2, H300 in accordance with Annex VI of CLP Regulation 1272/2008.