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EC number: 204-442-7 | CAS number: 121-00-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
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- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Nanomaterial pour density
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Classification of tert-butyl-4-methoxyphenol for effects in the environment
Several major guideline – estimation values (Klimisch 2) are available for tert-butyl-4-methoxyphenol, which indicates considerable toxic effect in the three key trophic levels (fish, invertebrates and algae) when exposed to the substance, tert-butyl-4-methoxyphenol at concentrations up to its limit of solubility in the respective test media. Among the values lower values which lead to the classification of the substance the value which have been considered for further calculation (algae) is EC50 = 1.9 mg/L.
In determining the classification appropriate to tert-butyl-4-methoxyphenol, it is necessary to consider all available evidence concerning its persistence, potential to accumulate and predicted or observed environmental fate and behaviour that may present a long-term and/or delayed danger to the structure and/or functioning of aquatic ecosystems. These points are considered below.
Persistence
Reliable studies are available to demonstrate that tert-butyl-4-methoxyphenol is non persistent in nature and so is considered to be biodegradable in the environment. In other words tert-butyl-4-methoxyphenol may therefore be expected to degrade rapidly. Thus it can be inferred that tert-butyl-4-methoxyphenol is non persistent in environment.
Potential to accumulate
Predicted and measured log Kow values for tert-butyl-4-methoxyphenol are less than 4 (Log Kow = 1). The potential for tert-butyl-4-methoxyphenol to bioaccumulate in the tissues of organisms that inhabit aquatic or terrestrial matrices is negligible as the BCF factor for the substance is less than 1000.
Thus,tert-butyl-4-methoxyphenolis non persistent and does not satisfy the criteria for classification as persistent (P).
The calculated BCF of cinnamaldehyde is 57.07 dimensionless and below the threshold of 2000.
So,tert-butyl-4-methoxyphenoldoes not satisfy the criterion for classification as bioaccumulative (B).
The toxicity values of fish, invertebrates and algae are LC50 = 2.5 mg/L, EC50 = 2.3 mg/L are EC50 = 1.9 mg/L, respectively. All the values of the 3 trophic levels fall in the criteria for classification (as per CLP regulation in category 2) and so will not qualify for classification as per the CLP regulation in the above mentioned criteria.
Tert-butyl-4-methoxyphenoldoes satisfy the environmental effects criterion for classification as toxic (T).
Tert-butyl-4-methoxyphenolis not P & B (or vPvB) substance, but will qualify as T.
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