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Description of key information

Toxicity of tert-butyl-4-methoxyphenol in any of the routes have been distinctly observed. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Standard acute method
GLP compliance:
not specified
Test type:
standard acute method
Species:
mouse
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 100 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Toxic Effects : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
Mortality:
Lethal dose, 50 percent kill
Clinical signs:
other: Toxic Effects : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral median lethal dose (LD50) of tert-butyl-4-methoxyphenol in mouse was found to be 1100 mg/kg of body weight. Acute oral toxicity of tert-butyl-4-methoxyphenol to mouse by oral route indicates that tert-butyl-4-methoxyphenol exhibits acute toxicity by the oral route in the Category 4 which is relatively non toxic.
Executive summary:

The acute oral median lethal dose (LD50) of tert-butyl-4-methoxyphenol in mouse was found to be 1100 mg/kg of body weight. Acute oral toxicity of tert-butyl-4-methoxyphenol to mouse by oral route indicates that tert-butyl-4-methoxyphenol exhibits acute toxicity by the oral route in the Category 4 which is relatively non toxic.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
1 100 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from QSAR toolbox Version 2.3
GLP compliance:
not specified
Test type:
other: Acute Rodent Inhalation Toxicity Test
Species:
mouse
Strain:
other: Swiss Webster
Sex:
not specified
Route of administration:
inhalation
Type of inhalation exposure:
other: Inhalation: Vapor
Vehicle:
not specified
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LC50
Effect level:
240.263 ppm
Based on:
test mat.
Remarks on result:
other: Other details not available

The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

(("a" and "b" ) and ("c" and "d" ) )

Domain logical expression index: "a"

Similarity boundary:Target: C(C)(C)(C)c1c(O)ccc(OC)c1
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Similarity boundary:Target: C(C)(C)(C)c1c(O)ccc(OC)c1
Threshold=60%,
Dice(Atom pairs)

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is >= 1.61

Domain logical expression index: "d"

Parametric boundary:The target chemical should have a value of log Kow which is <= 4.45

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Inhalation toxicity (LC50) of tert-butyl-4-methoxyphenol was examined in mouse at a dose concentration of 240.2633 mg/l.This value suggest that the chemical is non toxic by inhalation route.
Executive summary:
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Inhalation toxicity (LC50) of tert-butyl-4-methoxyphenol was examined in mouse at a dose concentration of 240.2633 mg/l.This value suggest that the chemical is non toxic by inhalation route.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LC50
Value:
240.263 mg/m³ air

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data from USEPA report
GLP compliance:
not specified
Test type:
standard acute method
Species:
rabbit
Strain:
not specified
Sex:
male/female
Type of coverage:
not specified
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
other: eye makeup preparation containing 0.1% BHA

Acute dermal testing rabbits of an eye makeup preparation containing 0.1% BHA yielded an LD50 > 2000 mg/kg.

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Based on the LD50 value of >2000 mg/kg for rabbit avaialble for tert-butyl-4-methoxyphenol, tt can be concluded that tert-butyl-4-methoxyphenol is not toxic via dermal route
Executive summary:

Based on the LD50 value of >2000 mg/kg for rabbit avaialble for tert-butyl-4-methoxyphenol, it can be concluded that tert-butyl-4-methoxyphenol is not toxic via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available
Dose descriptor:
LD50
Value:
2 100 mg/kg bw

Additional information

Acute toxicity: oral

The acute oral median lethal dose (LD50) of tert-butyl-4-methoxyphenol in rat was found to be 2000mg/kg of body weight.Acute oral toxicity of tert-butyl-4-methoxyphenol to rat by oral route indicates that tert-butyl-4-methoxyphenol exhibits acute toxicity by the oral route in the Category 4 which is relatively non toxic.

The other authoritative supporting sources of information also indicate the acute oral toxicity of tert-butyl-4-methoxyphenol to be in the range of 1100mg/kg of body weightto 2200mg/kg of body weight. However, for the purpose of the chemical safety report the experimental value will be considered.

Acute toxicity: inhalation

Inhalation toxicity (LC50) of tert-butyl-4-methoxyphenol was examined in mouse at a dose concentration of 240.2633 mg/m³ air.This value suggest that the chemical is non toxic by inhalation route.


Justification for selection of acute toxicity – oral endpoint
The acute oral median lethal dose (LD50) of tert-butyl-4-methoxyphenol in mouse was found to be 1100 mg/kg of body weight. Acute oral toxicity of tert-butyl-4-methoxyphenol to mouse by oral route indicates that tert-butyl-4-methoxyphenol exhibits acute toxicity by the oral route in the Category 4 which is relatively non toxic.

Justification for selection of acute toxicity – inhalation endpoint
Inhalation toxicity (LC50) of tert-butyl-4-methoxyphenol was examined in mouse at a dose concentration of 240.2633 mg/l.This value suggest that the chemical is non toxic by inhalation route.

Justification for selection of acute toxicity – dermal endpoint
Based on the LD50 value of >2000 mg/kg for rabbit avaialble for tert-butyl-4-methoxyphenol, it can be concluded that tert-butyl-4-methoxyphenol is not toxic via dermal route

Justification for classification or non-classification