Registration Dossier
Registration Dossier
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EC number: 204-442-7 | CAS number: 121-00-6
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- RTECS Number: SL1945000
- Author:
- RTECS Database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances) : NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 3,321,1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-tert-butyl-4-methoxyphenol
- EC Number:
- 204-442-7
- EC Name:
- 2-tert-butyl-4-methoxyphenol
- Cas Number:
- 121-00-6
- Molecular formula:
- C11H16O2
- IUPAC Name:
- 2-tert-butyl-4-methoxyphenol
- Details on test material:
- - Name of test material (as cited in study report): tert-butyl-4-methoxyphenol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Details on mating procedure:
- male 2 week(s) pre-mating female 2 week(s) pre-mating - 2 week(s) post-birth
- Duration of treatment / exposure:
- 2 week
- Control animals:
- not specified
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- LOEL
- Effect level:
- 30 000 mg/kg bw (total dose)
- Based on:
- test mat.
- Basis for effect level:
- other: developmental toxicity
Results (fetuses)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The toxicity (TDLo) of tert-butyl-4-methoxyphenol was tested in male/female rats by oral route shows effects as Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain). ; if the dose concentration reaches upto 30000 mg/kg bw (total dose).
- Executive summary:
The toxicity (TDLo) of tert-butyl-4-methoxyphenol was tested in male/female rats by oral route shows effects as Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain). ; if the dose concentration reaches upto 30000 mg/kg bw (total dose).
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