Registration Dossier

Diss Factsheets

Toxicological information

Developmental toxicity / teratogenicity

Currently viewing:

Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
RTECS Number: SL1945000
Author:
RTECS Database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances) : NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 3,321,1981

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from RTECS database
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-tert-butyl-4-methoxyphenol
EC Number:
204-442-7
EC Name:
2-tert-butyl-4-methoxyphenol
Cas Number:
121-00-6
Molecular formula:
C11H16O2
IUPAC Name:
2-tert-butyl-4-methoxyphenol
Details on test material:
- Name of test material (as cited in study report): tert-butyl-4-methoxyphenol
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rat
Strain:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Type of inhalation exposure (if applicable):
not specified
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Details on mating procedure:
male 2 week(s) pre-mating female 2 week(s) pre-mating - 2 week(s) post-birth
Duration of treatment / exposure:
2 week
Control animals:
not specified

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Dose descriptor:
LOEL
Effect level:
30 000 mg/kg bw (total dose)
Based on:
test mat.
Basis for effect level:
other: developmental toxicity

Results (fetuses)

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The toxicity (TDLo) of tert-butyl-4-methoxyphenol was tested in male/female rats by oral route shows effects as Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain). ; if the dose concentration reaches upto 30000 mg/kg bw (total dose).
Executive summary:

The toxicity (TDLo) of tert-butyl-4-methoxyphenol was tested in male/female rats by oral route shows effects as Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain). ; if the dose concentration reaches upto 30000 mg/kg bw (total dose).