Registration Dossier
Registration Dossier
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EC number: 204-442-7 | CAS number: 121-00-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from ACTOR database
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
- Species / strain / cell type:
- S. typhimurium TA 97
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium TA 100
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium TA 102
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium, other: TA104
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- RAT, LIVER, S-9, AROCLOR
- Test concentrations with justification for top dose:
- 1-1000 UG/PLATE
- Vehicle / solvent:
- DMSO
- Details on test system and experimental conditions:
- Test System : AMES SALMONELLA TYPHIMURIUM
Method : STANDARD PLATE - Species / strain:
- S. typhimurium TA 97
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium TA 102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium, other: TA104
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
- Conclusions:
- Interpretation of results (migrated information):
negative
In an Ames test , tert-butyl-4-methoxyphenol, in dimethyl sulfoxide from doses 1-1000 ug/plate was not mutagenic in Salmonella typhimurium strains TA97, TA100,TA102 and TA104 with and without addition of S9 liver fractions from Aroclor induced rats. - Executive summary:
In an Ames test , tert-butyl-4-methoxyphenol, in dimethyl sulfoxide from doses 1-1000 ug/plate was not mutagenic in Salmonella typhimurium strains TA97, TA100,TA102 and TA104 with and without addition of S9 liver fractions from Aroclor induced rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Sister chromatid exchange assay in mammalian cells (Rodent - hamster Fibroblast) for tert-butyl-4-methoxyphenol examined at the dose concentration 100 umol/L.
Justification for classification or non-classification
Studies suggest that the tert-butyl-4-methoxyphenol will not be classified in genetic toxicity category as per the C & L criteria set by EU.
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