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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
R: QSAR Toolbox 2.3.0.1132 prediction for LC50 read across evaluation for 25013-16-5
Author:
Sustainability Support Services
Year:
2012
Bibliographic source:
QSAR toolbox Version 2.3

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is from QSAR toolbox Version 2.3
GLP compliance:
not specified
Test type:
other: Acute Rodent Inhalation Toxicity Test

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): tert-butyl-4-methoxyphenol
- Substance type: Organic
- Physical state: Solid
- SMILES:C(C)(C)(C)c1c(O)ccc(OC)c1

Test animals

Species:
mouse
Strain:
other: Swiss Webster
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
other: Inhalation: Vapor
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
240.263 ppm
Based on:
test mat.
Remarks on result:
other: Other details not available

Any other information on results incl. tables

The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

(("a" and "b" ) and ("c" and "d" ) )

Domain logical expression index: "a"

Similarity boundary:Target: C(C)(C)(C)c1c(O)ccc(OC)c1
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Similarity boundary:Target: C(C)(C)(C)c1c(O)ccc(OC)c1
Threshold=60%,
Dice(Atom pairs)

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is >= 1.61

Domain logical expression index: "d"

Parametric boundary:The target chemical should have a value of log Kow which is <= 4.45

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Inhalation toxicity (LC50) of tert-butyl-4-methoxyphenol was examined in mouse at a dose concentration of 240.2633 mg/l.This value suggest that the chemical is non toxic by inhalation route.
Executive summary:
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Inhalation toxicity (LC50) of tert-butyl-4-methoxyphenol was examined in mouse at a dose concentration of 240.2633 mg/l.This value suggest that the chemical is non toxic by inhalation route.