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Ecotoxicological information

Long-term toxicity to fish

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Reference
Endpoint:
long-term toxicity to fish
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to
Guideline:
other: Modelling database
Principles of method if other than guideline:
Long term toxicity effect of test chemical on the mortality of fish.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
other: Fish
Test type:
flow-through
Water media type:
freshwater
Total exposure duration:
28 d
Reference substance (positive control):
no
Key result
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
0.761 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Neutral Organic SAR
Validity criteria fulfilled:
no
Conclusions:
The long term No Observed Effect Concentration (NOEC) for the test compound is estimated to be 0.761 mg/L.
Executive summary:

Using the EPI Suite, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a freshwater system, the no observed effect concentration (NOEC) value for the substance is estimated to be 0.761 mg/l for fish for 28 d duration.

Description of key information

Using the EPI Suite, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a freshwater system, the no observed effect concentration (NOEC) value for the substance is estimated to be 0.761 mg/l for fish for 28 d duration.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater fish:
0.761 mg/L

Additional information

Using the EPI Suite, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a freshwater system, the no observed effect concentration (NOEC) value for the substance is estimated to be 0.761 mg/l for fish for 28 d duration.