Registration Dossier
Registration Dossier
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EC number: 204-442-7 | CAS number: 121-00-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- GCID : 166796
- Author:
- HAGEMAN,GJ,et al.
- Year:
- 2 011
- Bibliographic source:
- ACToR (Aggregated Computational Toxicology Resource):[HAGEMAN,GJ,et al.;BUTYLATED HYDROXYANISOLE,BUTYLATED HYDROXYTOLUENE&TERTBUTYLHYDROQUINONE ARE NOT MUTAGENIC IN THE SALMONELLA/MICROSOME ASSAY USING NEW TESTER STRAINS;MUTA.RES.208(3-4):207-211, 1988]
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from ACTOR database
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2-tert-butyl-4-methoxyphenol
- EC Number:
- 204-442-7
- EC Name:
- 2-tert-butyl-4-methoxyphenol
- Cas Number:
- 121-00-6
- Molecular formula:
- C11H16O2
- IUPAC Name:
- 2-tert-butyl-4-methoxyphenol
- Details on test material:
- - Name of test material (as cited in study report): tert-butyl-4-methoxyphenol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 97
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium TA 100
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium TA 102
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium, other: TA104
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- RAT, LIVER, S-9, AROCLOR
- Test concentrations with justification for top dose:
- 1-1000 UG/PLATE
- Vehicle / solvent:
- DMSO
- Details on test system and experimental conditions:
- Test System : AMES SALMONELLA TYPHIMURIUM
Method : STANDARD PLATE
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 97
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium TA 102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium, other: TA104
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
In an Ames test , tert-butyl-4-methoxyphenol, in dimethyl sulfoxide from doses 1-1000 ug/plate was not mutagenic in Salmonella typhimurium strains TA97, TA100,TA102 and TA104 with and without addition of S9 liver fractions from Aroclor induced rats. - Executive summary:
In an Ames test , tert-butyl-4-methoxyphenol, in dimethyl sulfoxide from doses 1-1000 ug/plate was not mutagenic in Salmonella typhimurium strains TA97, TA100,TA102 and TA104 with and without addition of S9 liver fractions from Aroclor induced rats.
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