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Description of key information

The substance is not classified as irritating to skin and eye.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Multicase model
GLP compliance:
no
Species:
other: no data
Strain:
not specified
Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
no data
Remarks on result:
other: Skin irritation: negative i.e; non-irritating
Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Tert-butyl-4-methoxyphenol gives negative result i.e. not irritating to skin as estimated by the Multicase model from Danish QSAR .
Executive summary:

Tert-butyl-4-methoxyphenol gives negative result i.e. not irritating to skin as estimated by the Multicase model from Danish QSAR .

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from QSAR toolbox Version 2.3
GLP compliance:
not specified
Species:
rabbit
Strain:
not specified
Vehicle:
not specified
Controls:
not specified
Irritation parameter:
other: MMAS(modified maximum average score (MMAS))
Basis:
mean
Score:
0.94
Reversibility:
not specified
Remarks on result:
other: non irritating

The prediction was based on dataset comprised from the following descriptors: MMAS
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

(("a" and "b" ) and ("c" and "d" ) )

Domain logical expression index: "a"

Similarity boundary:Target: C(C)(C)(C)c1c(O)ccc(OC)c1
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Similarity boundary:Target: C(C)(C)(C)c1c(O)ccc(OC)c1
Threshold=80%,
Dice(Atom pairs)

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is >= 2.56

Domain logical expression index: "d"

Parametric boundary:The target chemical should have a value of log Kow which is <= 4.22

Interpretation of results:
not irritating
Remarks:
Migrated information 0.94 Criteria used for interpretation of results: EU
Conclusions:
By Modified maximum average score (MMAS) from prediction done using QSAR toolbox for eye irritation score of tert-butyl-4-methoxyphenol estimated as 0.94. This score indicates that tert-butyl-4-methoxyphenol is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).
Executive summary:

By Modified maximum average score (MMAS) from prediction done using QSAR toolbox for eye irritation score of tert-butyl-4-methoxyphenol estimated as 0.94. This score indicates that tert-butyl-4-methoxyphenol is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation / corrosion :

Tert-butyl-4-methoxyphenol gives negative result i.e. not irritating to skin as estimated by the Multicase model from Danish QSAR .

The other authoritative supporting sources of information indicates that tert-butyl-4-methoxyphenol exhibit moderate skin irritant effect when applied on rabbit skin. However, for the purpose of the chemical safety report the experimental value will be considered.

Eye irritation :

By Modified maximum average score (MMAS) from prediction done using QSAR toolbox for eye irritation score of tert-butyl-4-methoxyphenol estimated as 0.94. This score indicates that tert-butyl-4-methoxyphenol is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).


Justification for selection of skin irritation / corrosion endpoint:
Tert-butyl-4-methoxyphenol gives negative result i.e. not irritating to skin as estimated by the Multicase model from Danish QSAR .

Justification for selection of eye irritation endpoint:
By Modified maximum average score (MMAS) from prediction done using QSAR toolbox for eye irritation score of tert-butyl-4-methoxyphenol estimated as 0.94. This score indicates that tert-butyl-4-methoxyphenol is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).

Justification for classification or non-classification