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EC number: 204-442-7 | CAS number: 121-00-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The substance is not classified as irritating to skin and eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Multicase model
- GLP compliance:
- no
- Species:
- other: no data
- Strain:
- not specified
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- no data
- Remarks on result:
- other: Skin irritation: negative i.e; non-irritating
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Tert-butyl-4-methoxyphenol gives negative result i.e. not irritating to skin as estimated by the Multicase model from Danish QSAR .
- Executive summary:
Tert-butyl-4-methoxyphenol gives negative result i.e. not irritating to skin as estimated by the Multicase model from Danish QSAR .
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from QSAR toolbox Version 2.3
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Irritation parameter:
- other: MMAS(modified maximum average score (MMAS))
- Basis:
- mean
- Score:
- 0.94
- Reversibility:
- not specified
- Remarks on result:
- other: non irritating
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information 0.94 Criteria used for interpretation of results: EU
- Conclusions:
- By Modified maximum average score (MMAS) from prediction done using QSAR toolbox for eye irritation score of tert-butyl-4-methoxyphenol estimated as 0.94. This score indicates that tert-butyl-4-methoxyphenol is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).
- Executive summary:
By Modified maximum average score (MMAS) from prediction done using QSAR toolbox for eye irritation score of tert-butyl-4-methoxyphenol estimated as 0.94. This score indicates that tert-butyl-4-methoxyphenol is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).
Reference
The
prediction was based on dataset comprised from the following
descriptors: MMAS
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(("a"
and "b" )
and ("c"
and "d" )
)
Domain
logical expression index: "a"
Similarity
boundary:Target:
C(C)(C)(C)c1c(O)ccc(OC)c1
Threshold=50%,
Dice(Atom pairs)
Domain
logical expression index: "b"
Similarity
boundary:Target:
C(C)(C)(C)c1c(O)ccc(OC)c1
Threshold=80%,
Dice(Atom pairs)
Domain
logical expression index: "c"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 2.56
Domain
logical expression index: "d"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 4.22
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation / corrosion :
Tert-butyl-4-methoxyphenol gives negative result i.e. not irritating to skin as estimated by the Multicase model from Danish QSAR .
The other authoritative supporting sources of information indicates that tert-butyl-4-methoxyphenol exhibit moderate skin irritant effect when applied on rabbit skin. However, for the purpose of the chemical safety report the experimental value will be considered.
Eye irritation :
By Modified maximum average score (MMAS) from prediction done using QSAR toolbox for eye irritation score of tert-butyl-4-methoxyphenol estimated as 0.94. This score indicates that tert-butyl-4-methoxyphenol is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).
Justification for selection of skin irritation / corrosion endpoint:
Tert-butyl-4-methoxyphenol gives negative result i.e. not irritating to skin as estimated by the Multicase model from Danish QSAR .
Justification for selection of eye irritation endpoint:
By Modified maximum average score (MMAS) from prediction done using QSAR toolbox for eye irritation score of tert-butyl-4-methoxyphenol estimated as 0.94. This score indicates that tert-butyl-4-methoxyphenol is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).
Justification for classification or non-classification
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